thymol
Small moleculeexperimental
Thymol, a monoterpene, obtained from thyme oil or other volatile oils, is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions to help reduce and prevent plaque and gingivitis. Recently was shown, that this substance was able to significantly reduce the oxidative stress associated with cataract. The results suggested that thymol might be a potential therapeutic approach in the prevention of diabetic complications through its aldose reductase enzyme inhibitory and antioxidant activities. — NCATS
Clinical trial activity
5 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
1
Earliest trial started Feb 18, 2010 (NCT01079910)
Timeline
Indications
Approved for
Mechanism of action
- ErgosterolINHIBITOR
Ergosterol inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)C1=CC=C(C)C=C1O- Mol. weight
- 150.2176 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaThymol ↗
- NCATS3J50XA376E ↗
- ChEMBLCHEMBL29411 ↗
- NCATSA51HJM3XSU ↗
Also known as
- 2-isopropyl-5-methylphenol
- 2-isopropyl-5-methylphenol
- 2-isopropyl-5-methylphenol
- 2-isopropyl-5-methyl-phenol
- 5-methyl-2-(1-methylethyl)phenol
- 5-methyl-2-(1-methylethyl)phenol
- ipmp
- isopropylmethylphenol
- thyme camphor
- thymol
- thymol
- thymol
- thymol
- thymol
- thymol
- thymol
- thymol
- thymol
- thymol chrystals
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05427721 | Phase 2 | Apr 1, 2022 | Government of Mexico |
| NCT03767504 | N/A | Nov 13, 2018 | Innovus |
| NCT02202304 | Phase 4 | Sep 10, 2017 | Ivoclar Vivadent AG, University of Aberdeen |
| NCT02874963 | N/A | Nov 1, 2015 | University Clinical Centre of Kosova, University of Ljubljana |
| NCT01079910 | Phase 1 | Feb 18, 2010 | GlaxoSmithKline |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 1 | 1 | 1 | 2010 |
| Government of Mexico | Government | 1 | 1 | 1 | 2022 |
| Innovus | For profit | 1 | 1 | 1 | 2018 |
| Ivoclar Vivadent AG | For profit | 1 | 0 | 1 | 2017 |
| University Clinical Centre of Kosova | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Aberdeen | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Ljubljana | Academic/Hospital | 1 | 0 | 1 | 2015 |
7 organizations
Page 1 / 1