azd-0328
Small moleculeexperimental
Clinical trial activity
5 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2007 (NCT00687141)
Timeline
Indications
Mechanism of action
CHRNA7 agonist
Compound is listed in AstaZeneca's clinical and/or preclinical compound bank and available for research projects (http://openinnovation.astrazeneca.com/what-we-offer/compound/azd0328-2/).
Chemistry & pharmacology
Loading structure…
SMILES
c1cnc2c(c1)C[C@@]1(CN3CCC1CC3)O2- Mol. weight
- 216.28 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2151437 ↗
Also known as
- azd0328
- azd0328
- azd0328
- azd0328
- azd 0328
- azd-0328
- azd-0328
- azd-0328
- azd-0328
- spiro(1-azabicyclo(2.2.2)octane-3,2'(3h)-furo(2,3-b)pyridine)
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04810104 | Phase 2 | Apr 30, 2021 | AstraZeneca, European Commission, Masaryk University, Michael J. Fox Foundation for Parkinson's Research, Norges Parkinsonforbund, Norway, PARKINSONS UK, Stichting Lygature, University of Exeter, University of London, University of Stavanger |
| NCT00752830 | Phase 1 | Sep 1, 2008 | AstraZeneca |
| NCT00738959 | Phase 1 | Jun 1, 2008 | AstraZeneca, Richmond Pharmacology |
| NCT00669903 | Phase 2 | Apr 1, 2008 | AstraZeneca |
| NCT00687141 | Phase 1 | Nov 1, 2007 | AstraZeneca, IQVIA |
Showing 5 of 5 trials
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Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| AstraZeneca | For profit | 5 | 4 | 2 | 2007 |
| European Commission | Government | 1 | 0 | 1 | 2021 |
| IQVIA | For profit | 1 | 0 | 1 | 2007 |
| Masaryk University | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Michael J. Fox Foundation for Parkinson's Research | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Norges Parkinsonforbund, Norway | Academic/Hospital | 1 | 0 | 1 | 2021 |
| PARKINSONS UK | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Richmond Pharmacology | For profit | 1 | 0 | 1 | 2008 |
| Stichting Lygature | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of Exeter | Academic/Hospital | 1 | 0 | 1 | 2021 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2021 |
| University of Stavanger | Academic/Hospital | 1 | 0 | 1 | 2021 |
12 organizations
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