isoflavone
Botanicalexperimental
Isoflavones are a type of naturally occurring isoflavonoids, many of which act as phytoestrogens in mammals. Isoflavones occur in many plant species, but are especially high in soybeans. — Wikipedia
Clinical trial activity
26 trials · 32 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
14
Phase 3
5
Phase 4
3
Earliest trial started Feb 1, 2002 (NCT00030147)
Timeline
Indications
Approved for
Studied for
- Alzheimer Disease · Phase 2
- Atrophy · Phase 2
- Breast Neoplasms · Phase 2
- Climacteric · Phase 3
- Depression · Phase 4
- Diabetes, Gestational · Early Phase 1
- Flushing · Phase 2
- Hot Flashes · Phase 4
- Memory Disorders · Phase 2
- Menopause · Phase 3
- Pelvic Floor · Phase 4
- Postmenopause · Phase 3
- Prostatic Neoplasms · Phase 3
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
O=c1c(-c2ccccc2)coc2ccccc12- Mol. weight
- 222.24 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaIsoflavone ↗
- ChEMBLCHEMBL366460 ↗
- WikipediaRimostil ↗
Also known as
- isoflavona
- isoflavone
- isoflavone
- isoflavone
- isoflavones
- isoflavones
- novasoy
- rimostil
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03167827 | Phase 4 | Sep 30, 2016 | Federal University of Uberlandia |
| NCT02373111 | N/A | Mar 1, 2015 | Seoul National University |
| NCT03008785 | N/A | Feb 28, 2015 | Federal University of Uberlandia |
| NCT01695616 | Phase 3 | Aug 1, 2013 | Ache Laboratorios Farmaceuticos S.A. |
| NCT02806739 | Early Phase 1 (Phase 1) | Jan 1, 2013 | Hallmark Health System, Tufts University, University of Massachusetts |
| NCT03844685 | Phase 2 | Jul 5, 2012 | University of Milan |
| NCT01530893 | N/A | Feb 1, 2012 | University of East Anglia |
| NCT01754662 | N/A | Oct 1, 2011 | University of Hull |
| NCT01377961 | N/A | Sep 1, 2010 | University of Texas, Galveston |
| NCT01036321 | Phase 2 | Dec 1, 2009 | National Institutes of Health (NIH), University of South Florida |
| NCT00925639 | Phase 3 | Aug 1, 2009 | University of Sao Paulo |
| NCT00905723 | Phase 3 | May 1, 2009 | University of Sao Paulo |
| NCT00354432 | Phase 3 | Feb 1, 2007 | National Cancer Institute (NCI), Wake Forest University |
| NCT00861588 | N/A | Feb 1, 2006 | Chinese University of Hong Kong |
| NCT00245518 | Phase 4 | Jun 30, 2005 | Johns Hopkins University, National Cancer Institute (NCI) |
| NCT00205179 | Phase 2 | Jan 1, 2005 | National Institutes of Health (NIH), University of Wisconsin |
| NCT00594620 | Phase 2 | Aug 1, 2004 | Amgen, University of Kansas |
| NCT01553773 | Phase 2 | Jul 1, 2004 | University of Sao Paulo |
| NCT00204490 | Phase 2 | Apr 1, 2004 | National Cancer Institute (NCI), National Center for Research Resources (NCRR), University of Texas, Galveston |
| NCT00596895 | Phase 2 | Nov 1, 2003 | University of Florida |
Showing 20 of 26 trials
Page 1 / 2
Organizations
Research & Development (32)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 4 | 1 | 3 | 2002 |
| University of Sao Paulo | Academic/Hospital | 3 | 3 | 2 | 2004 |
| Federal University of Uberlandia | Academic/Hospital | 2 | 2 | 2 | 2015 |
| National Institute of Mental Health (NIMH) | Government | 2 | 2 | 2 | 2002 |
| National Institutes of Health (NIH) | Government | 2 | 0 | 1 | 2005 |
| University of Texas, Galveston | Academic/Hospital | 2 | 2 | 2 | 2004 |
| Ache Laboratorios Farmaceuticos S.A. | For profit | 1 | 1 | 1 | 2013 |
| Amgen | For profit | 1 | 0 | 1 | 2004 |
| Chinese University of Hong Kong | Academic/Hospital | 1 | 1 | 1 | 2006 |
| European Commission | Government | 1 | 0 | 1 | 2002 |
| Government of France | Government | 1 | 0 | 1 | 2002 |
| Hallmark Health System | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2003 |
| Johns Hopkins University | Academic/Hospital | 1 | 1 | 1 | 2005 |
| National Center for Complementary and Integrative Health (NCCIH) | Government | 1 | 1 | 1 | 2002 |
| National Center for Research Resources (NCRR) | Government | 1 | 0 | 1 | 2004 |
| Nichimo Co., Ltd | For profit | 1 | 0 | 1 | 2003 |
| Seoul National University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Solae, LLC | For profit | 1 | 0 | 1 | 2002 |
| TNO | For profit | 1 | 1 | 1 | 2002 |
32 organizations
Page 1 / 2