CDEK
← Mechanisms of action

TNFRSF8

SINGLE PROTEINHomo sapiens
Preferred name: Tumor necrosis factor receptor superfamily member 8 ChEMBL ↗

Linked proteins

Drugs acting on this target (25)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
sgn-30AgonistexperimentalmAbTNFRSF8 agonist
H22xKi-4AntagonistexperimentalmAbCD30
pra052AntagonistexperimentalmAbTNFRSF8 antagonist
brentuximab vedotin (adcetris)Binding agentapprovedmAbTumor necrosis factor receptor superfamily member 8 binding agent
gen3017Binding agentexperimentalmAbTNFRSF8 binding agent
hefi-1Binding agentexperimentalmAbTNFRSF8 binding agent
HRS-3/A9Binding agentexperimentalmAbCD30
anti-cd30 bispecific antibody-armed anti-cd3-activated autologous t-cells (cd30 biab-aatc)Immunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
autologous car.cd30 ebv specific-ctlsImmunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
car-t targeted cd19/cd20/cd22/cd30Immunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
cart30Immunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
cd30 car-t cellImmunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
cd30-car t cellsImmunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
cd30.car-ebvstImmunity, passiveexperimentalCell therapyimmunity, passive - CD30
icar30 t cellsImmunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
lcar-hl30 cellsImmunity, passiveexperimentalCell therapyTNFRSF8 immunity, passive
afm13InhibitorexperimentalmAbTNFRSF8 inhibitor
brentuximab vedotin (adcetris)InhibitorapprovedmAbTNFRSF8 inhibitor
f0002-adcInhibitorexperimentalmAbTNFRSF8 inhibitor
hefi-1InhibitorexperimentalmAbTNFRSF8 inhibitor
iratumumabInhibitorexperimentalmAbTNFRSF8 inhibitor
mdx-1401InhibitorexperimentalmAbTNFRSF8 inhibitor
sgn-30InhibitorexperimentalmAbTNFRSF8 inhibitor
xmab2513InhibitorexperimentalmAbTNFRSF8 inhibitor
iratumumabOtherexperimentalmAbTNFRSF8 other