← Mechanisms of action
ABL1
SINGLE PROTEINHomo sapiens
Preferred name: Tyrosine-protein kinase ABL ChEMBL ↗
Linked proteins
Drugs acting on this target (19)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| abl-001 | Inhibitor | experimental | mAb | ABL1 inhibitor |
| asciminib (Scemblix) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase ABL inhibitor |
| at9283 | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| azd-0424 | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| azm-475271 | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| bafetinib | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| bosutinib (bosulif) | Inhibitor | approved | Small molecule | ABL1 inhibitor |
| dasatinib (sprycel) | Inhibitor | approved | Small molecule | ABL1 inhibitor |
| flumatinib | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| imatinib (gleevec) | Inhibitor | approved | Small molecule | ABL1 inhibitor |
| kw2449 | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| nilotinib (tasigna) | Inhibitor | approved | Small molecule | ABL1 inhibitor |
| ponatinib (iclusig) | Inhibitor | approved | Small molecule | ABL1 inhibitor |
| rebastinib | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| regorafenib (stivarga) | Inhibitor | approved | Small molecule | ABL1 inhibitor |
| saracatinib | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| sklb1028 | Inhibitor | experimental | Small molecule | ABL1 inhibitor |
| umbralisib (Ukoniq) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase ABL inhibitor |
| xl228 | Inhibitor | experimental | Small molecule | ABL1 inhibitor |