← Mechanisms of action
DHFR
SINGLE PROTEINHomo sapiens
Preferred name: Dihydrofolate reductase ChEMBL ↗
Linked proteins
Drugs acting on this target (6)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| aminopterin | Inhibitor | experimental | Small molecule | DHFR inhibitor |
| methotrexate | Inhibitor | experimental | Small molecule | DHFR inhibitor |
| naltrexone (revia) | Inhibitor | approved | Small molecule | DHFR inhibitor |
| pemetrexed (alimta) | Inhibitor | approved | Small molecule | DHFR inhibitor |
| piritrexim | Inhibitor | experimental | Small molecule | Dihydrofolate reductase inhibitor |
| pralatrexate (folotyn) | Inhibitor | approved | Small molecule | DHFR inhibitor |