← Mechanisms of action
ROS1
SINGLE PROTEINHomo sapiens
Preferred name: Proto-oncogene tyrosine-protein kinase ROS ChEMBL ↗
Linked proteins
Drugs acting on this target (16)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| lorlatinib (lorbrena) | Antagonist | approved | Small molecule | ROS1 antagonist |
| tgrx-326 | Antagonist | experimental | Small molecule | ROS1 |
| ans03 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| apg-2449 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| crizotinib (xalkori) | Inhibitor | approved | Small molecule | Proto-oncogene tyrosine-protein kinase ROS inhibitor |
| ds6051b | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| entrectinib (Rozlytrek) | Inhibitor | approved | Small molecule | Proto-oncogene tyrosine-protein kinase ROS inhibitor |
| jyp0322 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| nvl-520 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| repotrectinib (Augtyro) | Inhibitor | approved | Small molecule | ROS1 inhibitor |
| sim1803-1a | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| taletrectinib | Inhibitor | approved | Small molecule | ROS1 inhibitor |
| tq-b3101 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| ty-2136b | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| xzp-3621 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |
| xzp-5955 | Inhibitor | experimental | Small molecule | ROS1 inhibitor |