CDEK
← Mechanisms of action

F8

SINGLE PROTEINHomo sapiens
Preferred name: Coagulation factor VIII ChEMBL ↗

Linked proteins

Drugs acting on this target (43)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
antihemophilic factor viii (Recombinant), Fc-fusion protein (Eloctate)AgonistapprovedRecombinant proteinF8 agonist
antihemophilic factor viii (Recombinant), porcine sequence (Obizur)AgonistapprovedRecombinant proteinF8 agonist
antihemophilic factor viii (Recombinant), single chain (Afstyla)AgonistapprovedRecombinant proteinF8 agonist
antihemophilic factor viii human (Hemofil M)AgonistapprovedBiologicalF8 agonist
Giroctocogene FitelparvovecExogenous geneexperimentalGene therapyCoagulation factor VIII exogenous gene
antihemophilic factor viii (Recombinant) (Adynovate)Exogenous proteinapprovedRecombinant proteinCoagulation factor VIII exogenous protein
antihemophilic factor viii (Recombinant), porcine sequence (Obizur)Exogenous proteinapprovedRecombinant proteinCoagulation factor VIII exogenous protein
antihemophilic factor viii (Recombinant), single chain (Afstyla)Exogenous proteinapprovedRecombinant proteinCoagulation factor VIII exogenous protein
bivv001 (Advate)Exogenous proteinexperimentalRecombinant proteinCoagulation factor VIII exogenous protein
moroctocog-alfaExogenous proteinexperimentalRecombinant proteinCoagulation factor VIII exogenous protein
turoctocog alfaExogenous proteinexperimentalRecombinant proteinCoagulation factor VIII exogenous protein
drotrecogin alfa, activated (Xigris)InhibitorapprovedRecombinant proteinF8 inhibitor
emicizumab (Hemlibra)InhibitorapprovedmAbF8 inhibitor
nnc0365-3769 aInhibitorexperimentalmAbF8 inhibitor
ss109InhibitorexperimentalSmall moleculeF8 inhibitor
tb-402InhibitorexperimentalmAbF8 inhibitor
aav2/6 human factor viiiSupplementationexperimentalGene therapyF8 supplementation
aav2/8-hlp-fviii-v3SupplementationexperimentalGene therapyF8 supplementation
anb-010SupplementationexperimentalGene therapyF8 supplementation
antihemophilic factor (recombinant), fc-vwf-xten fusion protein-ehtl (ALTUVIIIO)SupplementationapprovedRecombinant proteinF8 supplementation
antihemophilic factor viii (Recombinant) (Adynovate)SupplementationapprovedRecombinant proteinF8 supplementation
antihemophilic factor viii (Recombinant), porcine sequence (Obizur)SupplementationapprovedRecombinant proteinF8 supplementation
asc618SupplementationexperimentalGene therapyF8 supplementation
auto cd34 pbsc transduced with a lentiviral vector encoding a novel coagulation factor viii transgeneSupplementationexperimentalCell therapyF8 supplementation
auto cd34 pbsc transduced with a lentiviral vector encoding a novel coagulation factor viii transgeneSupplementationexperimentalCell therapyF8 supplementation
bay2599023SupplementationexperimentalGene therapyF8 supplementation
bbm 002SupplementationexperimentalGene therapyF8 supplementation
bbm-h803SupplementationexperimentalGene therapyF8 supplementation
bivv001 (Advate)SupplementationexperimentalRecombinant proteinF8 supplementation
Giroctocogene FitelparvovecSupplementationexperimentalGene therapyF8 supplementation
gs1191SupplementationexperimentalGene therapyF8 supplementation
human transfer factorSupplementationexperimentalBiologicalF8 supplementation
moroctocog-alfaSupplementationexperimentalRecombinant proteinF8 supplementation
nggt003SupplementationexperimentalGene therapyF8 supplementation
nnc0442-0344SupplementationexperimentalRecombinant proteinF8 supplementation
nonacog beta pegolSupplementationexperimentalBiologicalF8 supplementation
rurioctocog alfa pegolSupplementationexperimentalRecombinant proteinF8 supplementation
sct800SupplementationexperimentalRecombinant proteinF8 supplementation
spk-8011SupplementationexperimentalGene therapyF8 supplementation
spk-8016SupplementationexperimentalGene therapyF8 supplementation
turoctocog alfaSupplementationexperimentalRecombinant proteinF8 supplementation
valoctocogene roxaparvovec (Roctavian)SupplementationapprovedGene therapyF8 supplementation
yuva-gt-f801SupplementationexperimentalGene therapyF8 supplementation