← Mechanisms of action
TP53
SINGLE PROTEINHomo sapiens
Preferred name: Cellular tumor antigen p53 ChEMBL ↗
Linked proteins
Drugs acting on this target (28)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| coti2 | Activator | experimental | Small molecule | TP53 activator |
| gensci128 | Activator | experimental | Small molecule | TP53 activator |
| inv-102 | Activator | experimental | Small molecule | TP53 activator |
| pc14586 | Activator | experimental | Small molecule | TP53 activator |
| rezatapopt | Activator | experimental | Small molecule | TP53 activator |
| cenersen | Agonist | experimental | Nucleic acid | TP53 agonist |
| qpi-1002 | Agonist | experimental | Nucleic acid | TP53 agonist |
| ubx0101 | Antagonist | experimental | Small molecule | TP53 antagonist |
| i5np | Antisense inhibitor | experimental | Nucleic acid | TP53 antisense inhibitor |
| autologous, engineered t cells targeting tp53 r175h | Immunity, active | experimental | Cell therapy | TP53 immunity, active |
| modified vaccinia virus ankara vaccine expressing p53 | Immunity, active | experimental | Vaccine | TP53 immunity, active |
| p53 peptide vaccine | Immunity, active | experimental | Biological | TP53 immunity, active |
| p53-slp | Immunity, active | experimental | Biological | TP53 immunity, active |
| anti-p53 t-cell receptor-transduced peripheral blood lymphocytes | Immunity, passive | experimental | Gene therapy | TP53 immunity, passive |
| tp53-epha-2-car-dc | Immunity, passive | experimental | Cell therapy | TP53 immunity, passive |
| alt-801 | Inhibitor | experimental | Recombinant protein | TP53 inhibitor |
| apr-548 | Inhibitor | experimental | Small molecule | TP53 inhibitor |
| azurin-derived cell-penetrating peptide p28 | Inhibitor | experimental | Peptide | TP53 inhibitor |
| clsp-1025 | Inhibitor | experimental | mAb | TP53 inhibitor |
| jab-30355 | Inhibitor | experimental | Small molecule | TP53 inhibitor |
| transferrin receptor-targeted liposomal p53 cdna | Inhibitor | experimental | Gene therapy | TP53 inhibitor |
| ivaltinostat | Modulator | experimental | Small molecule | TP53 modulator |
| Eprenetapopt | Stabiliser | experimental | Small molecule | Cellular tumor antigen p53 stabiliser |
| Eprenetapopt | Supplementation | experimental | Small molecule | TP53 supplementation |
| ingn 201 (advexin) | Supplementation | experimental | Gene therapy | TP53 supplementation |
| recombinant adenoviral human p53 gene | Supplementation | experimental | Gene therapy | TP53 supplementation |
| sch-58500 | Supplementation | experimental | Gene therapy | TP53 supplementation |
| sgt-53 | Supplementation | experimental | Gene therapy | TP53 supplementation |