← Mechanisms of action
TYK2
SINGLE PROTEINHomo sapiens
Preferred name: Tyrosine-protein kinase TYK2 ChEMBL ↗
Linked proteins
Drugs acting on this target (41)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| esk-001 | Antagonist | experimental | Small molecule | Tyk2 |
| icp-332 | Antagonist | experimental | Small molecule | TYK2 |
| icp-488 | Antagonist | experimental | Small molecule | TYK2 |
| a-005 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| a51r2 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| abbv-722 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| bgb-23339 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| bhv-8000 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| blkr201 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| bms-986202 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| bms-986482 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| bms-986482 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| Brepocitinib | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| cerdulatinib | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| cms-d001 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| cs32582 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| d-2570 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| deuruxolitinib | Inhibitor | approved | Small molecule | Tyrosine-protein kinase TYK2 inhibitor |
| filgotinib (Jyseleca) | Inhibitor | experimental | Small molecule | Tyrosine-protein kinase TYK2 inhibitor |
| glpg3121 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| glpg3667 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| hs-10374 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| max-40070 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| neu-627 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| ost-122 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| pf-06826647 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| pf06263276 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| qy201 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| syhx 1901 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| syhx1901 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| tdm-180935 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| tll-018 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| tll018 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| tqh3906 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| ty-2136b | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| vtx958 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| vvn461 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| wd-890 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| wd-910 | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| zasocitinib | Inhibitor | experimental | Small molecule | TYK2 inhibitor |
| deucravacitinib (Sotkyktu) | Negative allosteric modulator | approved | Small molecule | Tyrosine-protein kinase TYK2 negative allosteric modulator |