← Mechanisms of action

NS5b

SINGLE PROTEINHepacivirus hominis

Preferred name: RNA-directed RNA polymerase ChEMBL ↗

Linked proteins

RNA-directed RNA polymerase (NS5b) ↗

Drugs acting on this target (18)

Active Pharmaceutical Ingredient	Mechanism Type ▲	Approval Status	API Type	Mechanism of Action
balapiravir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
bms-986094	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
dasabuvir (Exviera)	Inhibitor	approved	Small molecule	RNA-directed RNA polymerase inhibitor
deleobuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
filibuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
mericitabine	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
nesbuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
psi-352938	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
radalbuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
ribavirin (virazole)	Inhibitor	approved	Small molecule	RNA-directed RNA polymerase inhibitor
setrobuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
sofosbuvir (sovaldi)	Inhibitor	approved	Small molecule	RNA-directed RNA polymerase inhibitor
tegobuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
tmc-647055	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
uprifosbuvir	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
valopicitabine	Inhibitor	experimental	Small molecule	RNA-directed RNA polymerase inhibitor
beclabuvir	Negative allosteric modulator	experimental	Small molecule	RNA-directed RNA polymerase negative allosteric modulator
lomibuvir	Negative allosteric modulator	experimental	Small molecule	RNA-directed RNA polymerase negative allosteric modulator