CDEK
← Mechanisms of action

FOLH1

SINGLE PROTEINHomo sapiens
Preferred name: Glutamate carboxypeptidase II ChEMBL ↗

Linked proteins

Drugs acting on this target (138)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
Hu591AdccexperimentalmAbFOLH1 adcc
menadiol (synkavite)AgonistapprovedSmall moleculeFOLH1 agonist
cb307AntagonistexperimentalmAbFOLH1 antagonist
[111in]in-fl-020Binding agentexperimentalSmall moleculeFOLH1 binding agent
[177lu]lu-akir001Binding agentexperimentalPeptideFOLH1 binding agent
[177lu]lu-psma-137Binding agentexperimentalPeptideFOLH1 binding agent
[225ac]ac-fl-020Binding agentexperimentalSmall moleculeFOLH1 binding agent
111in-j591Binding agentexperimentalmAbFOLH1 binding agent
161tb-sibudabBinding agentexperimentalSmall moleculeFOLH1 binding agent
177lu-dansyl-psmaBinding agentexperimentalPeptideFOLH1 binding agent
177lu-dota-tlx591Binding agentexperimentalmAbFOLH1 binding agent
177lu-lnc1011Binding agentexperimentalPeptideFOLH1 binding agent
177lu-nym032Binding agentexperimentalPeptideFOLH1 binding agent
177lu-psma-r2Binding agentexperimentalSmall moleculeFOLH1 binding agent
18f dcfbcBinding agentexperimentalSmall moleculeFOLH1 binding agent
18f-jk-psma-7Binding agentexperimentalPeptideFOLH1 binding agent
61cu-nodaga-lm3Binding agentexperimentalSmall moleculeFOLH1 binding agent
68ga-aazta-093Binding agentexperimentalSmall moleculeFOLH1 binding agent
arx517Binding agentexperimentalmAbFOLH1 binding agent
bay2010112Binding agentexperimentalmAbFOLH1 binding agent
bay2315493Binding agentexperimentalPeptideFOLH1 binding agent
bay3546828Binding agentexperimentalmAbFOLH1 binding agent
cb307Binding agentexperimentalmAbFOLH1 binding agent
cbp-1018Binding agentexperimentalmAbFOLH1 binding agent
cc-1Binding agentexperimentalmAbFOLH1 binding agent
cyt-356-y-90 (Oncoltad)Binding agentexperimentalmAbFOLH1 binding agent
cyt-500Binding agentexperimentalmAbFOLH1 binding agent
ec1169Binding agentexperimentalSmall moleculeFOLH1 binding agent
Ga 68 PSMA-11 (Illuccix)Binding agentapprovedSmall moleculeFOLH1 binding agent
gsk5458514Binding agentexperimentalmAbFOLH1 binding agent
htk03170Binding agentexperimentalPeptideFOLH1 binding agent
inr101Binding agentexperimentalSmall moleculeFOLH1 binding agent
janx007Binding agentexperimentalmAbFOLH1 binding agent
jnj-80038114Binding agentexperimentalRecombinant proteinFOLH1 binding agent
lutetium (177Lu) vipivotide tetraxetan (Pluvicto)Binding agentapprovedSmall moleculeFOLH1 binding agent
mln-2704Binding agentexperimentalmAbFOLH1 binding agent
mor209Binding agentexperimentalmAbFOLH1 binding agent
piflufolastat (PYLARIFY)Binding agentapprovedSmall moleculeFOLH1 binding agent
pnt2002Binding agentexperimentalPeptideFOLH1 binding agent
regn4336Binding agentexperimentalmAbFOLH1 binding agent
TNB-585Binding agentexperimentalmAbFOLH1 binding agent
human prostate-specific membrane antigen plasmid dna vaccineImmunity, activeexperimentalVaccineFOLH1 immunity, active
ino-5150Immunity, activeexperimentalVaccineFOLH1 immunity, active
mouse prostate-specific membrane antigen plasmid dna vaccineImmunity, activeexperimentalVaccineFOLH1 immunity, active
prostate specific membrane antigenImmunity, activeexperimentalVaccineFOLH1 immunity, active
rspsma proteinImmunity, activeexperimentalVaccineFOLH1 immunity, active
131i-psma-1095Immunity, passiveexperimentalmAbFOLH1 immunity, passive
177lu-cyt-500Immunity, passiveexperimentalmAbFOLH1 immunity, passive
177lu-psma-i&tImmunity, passiveexperimentalmAbFOLH1 immunity, passive
4scar-psmaImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
89zr df-iab2mImmunity, passiveexperimentalmAbFOLH1 immunity, passive
89zr-df-iab2mImmunity, passiveexperimentalmAbFOLH1 immunity, passive
ab-2100Immunity, passiveexperimentalCell therapyFOLH1 immunity, passive
amg 160Immunity, passiveexperimentalmAbFOLH1 immunity, passive
amg 171Immunity, passiveexperimentalmAbFOLH1 immunity, passive
anti-psma car nk cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
anti-psma designer t cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
bay 2315497Immunity, passiveexperimentalmAbFOLH1 immunity, passive
bi-4scar gd2/psma t cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
cart-psma-tgfbetardn cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
cyt-356-y-90 (Oncoltad)Immunity, passiveexperimentalmAbFOLH1 immunity, passive
cyt-500Immunity, passiveexperimentalmAbFOLH1 immunity, passive
gd2, psma and cd276 car-t cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
hpn424Immunity, passiveexperimentalmAbFOLH1 immunity, passive
jnj-63898081Immunity, passiveexperimentalmAbFOLH1 immunity, passive
lu177 monoclonal antibody j591Immunity, passiveexperimentalmAbFOLH1 immunity, passive
mdx-070Immunity, passiveexperimentalmAbFOLH1 immunity, passive
mdx1201-a488Immunity, passiveexperimentalmAbFOLH1 immunity, passive
medi3726Immunity, passiveexperimentalmAbFOLH1 immunity, passive
mln-2704Immunity, passiveexperimentalmAbFOLH1 immunity, passive
mor209Immunity, passiveexperimentalmAbFOLH1 immunity, passive
pd1-psma-cart cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
psma car-t cellImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
regn5678Immunity, passiveexperimentalmAbFOLH1 immunity, passive
regn7075Immunity, passiveexperimentalmAbFOLH1 immunity, passive
tmpsma-02Immunity, passiveexperimentalCell therapyFOLH1 immunity, passive
tmpsma-02 car t cellsImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
unicar02-t-ppsmaImmunity, passiveexperimentalCell therapyFOLH1 immunity, passive
225ac-psmaInhibitorexperimentalPeptideFOLH1 inhibitor
225ac−j591InhibitorexperimentalmAbFOLH1 inhibitor
64cu-psma iInhibitorexperimentalPeptideFOLH1 inhibitor
64cu-psma i&tInhibitorexperimentalPeptideFOLH1 inhibitor
abbv-969InhibitorexperimentalmAbFOLH1 inhibitor
capromab pendetide (Prostascint)InhibitorapprovedmAbFOLH1 inhibitor
ctt1403InhibitorexperimentalRecombinant proteinFOLH1 inhibitor
dgpr1008InhibitorexperimentalSmall moleculeFOLH1 inhibitor
dxc014InhibitorexperimentalmAbFOLH1 inhibitor
f-18-psma-1007InhibitorexperimentalRecombinant proteinFOLH1 inhibitor
gensci143InhibitorexperimentalmAbFOLH1 inhibitor
jnj-87189401InhibitorexperimentalmAbFOLH1 inhibitor
lava-1207InhibitorexperimentalmAbFOLH1 inhibitor
lu177 monoclonal antibody j591InhibitorexperimentalmAbFOLH1 inhibitor
mhb048cInhibitorexperimentalmAbFOLH1 inhibitor
monoclonal antibody muj591InhibitorexperimentalmAbFOLH1 inhibitor
N-acetyl-aspartyl-glutamateInhibitorexperimentalSmall moleculeFOLH1 inhibitor
psmaxcd3InhibitorexperimentalmAbFOLH1 inhibitor
psw-1025InhibitorexperimentalSmall moleculeFOLH1 inhibitor
td001InhibitorexperimentalmAbFOLH1 inhibitor
thp-psmaInhibitorexperimentalRecombinant proteinFOLH1 inhibitor
tris-pocInhibitorexperimentalSmall moleculeFOLH1 inhibitor
mdx-070OtherexperimentalmAbFOLH1 other
[177lu]lu-bq7876RadiodepletionexperimentalPeptideFOLH1 radiodepletion
[203pb]pb-dotam-mam279RadiodepletionexperimentalPeptideFOLH1 radiodepletion
[211at]naatRadiodepletionexperimentalSmall moleculeFOLH1 radiodepletion
[ac-225]-psma-62RadiodepletionexperimentalPeptideFOLH1 radiodepletion
111in-j591RadiodepletionexperimentalmAbFOLH1 radiodepletion
131i-mip-1095RadiodepletionexperimentalSmall moleculeFOLH1 radiodepletion
161tb-lnc1011RadiodepletionexperimentalmAbFOLH1 radiodepletion
177lu-nym096RadiodepletionexperimentalSmall moleculeFOLH1 radiodepletion
225ac-lnc1011RadiodepletionexperimentalPeptideFOLH1 radiodepletion
actinium (225ac) rhpsma-10.1RadiodepletionexperimentalRecombinant proteinFOLH1 radiodepletion
actinium ac 225 vipivotide tetraxetanRadiodepletionexperimentalPeptideFOLH1 radiodepletion
in-111 rosopatamab tetraxetanRadiodepletionexperimentalmAbFOLH1 radiodepletion
inr102RadiodepletionexperimentalPeptideFOLH1 radiodepletion
(64cu)-nota-psmai-peg-cy5.5-cRadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
(89zr)-dfo-psmai-peg-cy5.5-cRadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
[ 161 tb]tb psmaRadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
[18f]f-psma-n5RadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
[68ga]p3RadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
177lu-psma-eb-01RadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
212pb-ng001RadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
⁶⁸ga-fc516RadiopharmaceuticalexperimentalmAbFOLH1 radiopharmaceutical
68ga-nym096RadiopharmaceuticalexperimentalmAbFOLH1 radiopharmaceutical
68ga-psfaRadiopharmaceuticalexperimentalmAbFOLH1 radiopharmaceutical
89zr-j591RadiopharmaceuticalexperimentalmAbFOLH1 radiopharmaceutical
99mtc-qulic-5-p1RadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
bay1075553RadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
copper 61-psmaRadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
dcfbcRadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
ec0652RadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
Fc303RadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
Flotufolastat (Posluma)RadiopharmaceuticalapprovedPeptideFOLH1 radiopharmaceutical
gozetotideRadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
lu-177-dgulRadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
lu-177-itg-psma-1RadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
p16-093RadiopharmaceuticalexperimentalSmall moleculeFOLH1 radiopharmaceutical
xt033RadiopharmaceuticalexperimentalPeptideFOLH1 radiopharmaceutical
99mtc psmaReducing agentexperimentalPeptideFOLH1 reducing agent