← Mechanisms of action
DLL3
SINGLE PROTEINHomo sapiens
Preferred name: Delta-like protein 3 ChEMBL ↗
Linked proteins
Drugs acting on this target (23)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| pt217 | Antagonist | experimental | mAb | DLL3 |
| 177lu-dtpa-sc16.56 | Binding agent | experimental | Peptide | DLL3 binding agent |
| qls31904 | Binding agent | experimental | mAb | DLL3 |
| rovalpituzumab tesirine | Binding agent | experimental | mAb | Delta-like protein 3 binding agent |
| tarlatamab (IMDELLTRA) | Binding agent | approved | mAb | Delta-like protein 3 binding agent |
| amg 119 | Immunity, passive | experimental | Cell therapy | immunity, passive - DLL3 |
| dll3-car-nk cells | Immunity, passive | experimental | Cell therapy | immunity, passive - DLL3 |
| gc511b car-t cell | Immunity, passive | experimental | Cell therapy | DLL3 immunity, passive |
| bi 764532 | Inhibitor | experimental | mAb | DLL3 inhibitor |
| fz-ad005 | Inhibitor | experimental | mAb | DLL3 inhibitor |
| hpn328 | Inhibitor | experimental | mAb | DLL3 inhibitor |
| lb2102 | Inhibitor | experimental | Small molecule | inhibitor - DLL3 |
| ro7616789 | Inhibitor | experimental | mAb | inhibitor - DLL3 |
| rovalpituzumab tesirine | Inhibitor | experimental | mAb | DLL3 inhibitor |
| sc002 | Inhibitor | experimental | mAb | DLL3 inhibitor |
| sl-172154 | Inhibitor | experimental | mAb | DLL3 inhibitor |
| sys6040 | Inhibitor | experimental | mAb | DLL3 inhibitor |
| tarlatamab (IMDELLTRA) | Inhibitor | approved | mAb | DLL3 inhibitor |
| 225ac-abd147 | Radiodepletion | experimental | mAb | DLL3 radiodepletion |
| 225ac-etn029 | Radiodepletion | experimental | Peptide | DLL3 radiodepletion |
| 111in-abd147 | Radiopharmaceutical | experimental | Recombinant protein | DLL3 radiopharmaceutical |
| 111in-etn029 | Radiopharmaceutical | experimental | Small molecule | DLL3 radiopharmaceutical |
| 89zr-dfo-sc16.56 | Radiopharmaceutical | experimental | mAb | DLL3 radiopharmaceutical |