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Proto-Oncogene Proteins
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Subtype terms (66)
More specific conditions that are subtypes of Proto-Oncogene Proteins in the MeSH hierarchy.
- Axl Receptor Tyrosine Kinase
- B-Cell Lymphoma 3 Protein
- Bcl-2-Like Protein 11
- Chemokine CXCL1
- c-Mer Tyrosine Kinase
- Cyclin D1
13 drugs (11 approved, 2 experimental)
- Erb-b2 Receptor Tyrosine Kinases
13 drugs (11 approved, 2 experimental)
- Fibroblast Growth Factor 4
- Fibroblast Growth Factor 6
- fms-Like Tyrosine Kinase 3
- Janus Kinase 2
- KRIT1 Protein
- Kruppel-Like Factor 6
- Lipocalin-2
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- MDS1 and EVI1 Complex Locus Protein
- MutS Homolog 2 Protein
- Myeloid-Lymphoid Leukemia Protein
- N-Myc Proto-Oncogene Protein
10 drugs (8 approved, 2 experimental)
- Pre-B-Cell Leukemia Transcription Factor 1
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-abl
- Proto-Oncogene Proteins c-akt
1 drug experimental
- Proto-Oncogene Proteins c-bcl-2
- Proto-Oncogene Proteins c-bcl-6
- Proto-Oncogene Proteins c-bcr
- Proto-Oncogene Proteins c-cbl
- Proto-Oncogene Proteins c-crk
- Proto-Oncogene Proteins c-ets
- Proto-Oncogene Proteins c-fes
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-fyn
- Proto-Oncogene Proteins c-hck
- Proto-Oncogene Proteins c-jun
- Proto-Oncogene Proteins c-kit
3 drugs approved
- Proto-Oncogene Proteins c-maf
- Proto-Oncogene Proteins c-mdm2
- Proto-Oncogene Proteins c-met
19 drugs (14 approved, 5 experimental)
- Proto-Oncogene Proteins c-mos
- Proto-Oncogene Proteins c-myb
- Proto-Oncogene Proteins c-myc
- Proto-Oncogene Proteins c-pim-1
- Proto-Oncogene Proteins c-rel
- Proto-Oncogene Proteins c-ret
- Proto-Oncogene Proteins c-sis
- Proto-Oncogene Proteins c-vav
- Proto-Oncogene Proteins c-yes
- Proto-Oncogene Proteins p21(ras)
10 drugs (7 approved, 3 experimental)
- Proto-Oncogene Protein Spi-1
- Proto-Oncogene Proteins pp60(c-src)
- raf Kinases
- Receptor, ErbB-3
- Receptor, ErbB-4
- Receptor, Fibroblast Growth Factor, Type 3
4 drugs experimental
- Receptor, Macrophage Colony-Stimulating Factor
- Receptor, Notch4
- Receptors, Thyroid Hormone
- RNA-Binding Protein EWS
- RNA-Binding Protein FUS
- RUNX1 Translocation Partner 1 Protein
4 drugs approved
- Stathmin
- T-Cell Acute Lymphocytic Leukemia Protein 1
- Wnt1 Protein
- Wnt2 Protein
- Wnt-5a Protein
- Zinc Finger Protein GLI1