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Immune Checkpoint Proteins
Immunomodulators that regulate immune system either in stimulatory or inhibitory fashion allowing IMMUNE TOLERANCE. Activation of suppressed immune system (IMMUNOSUPPRESSION (PHYSIOLOGY)) in immunotherapy by IMMUNE CHECKPOINT INHIBITORS often targets inhibitory checkpoint molecules.
Subtype terms (10)
More specific conditions that are subtypes of Immune Checkpoint Proteins in the MeSH hierarchy.
- B7-2 Antigen
- B7-H1 Antigen
3 drugs (2 approved, 1 experimental)
- CD40 Antigens
- CTLA-4 Antigen
3 drugs (2 approved, 1 experimental)
- Hepatitis A Virus Cellular Receptor 2
- Lymphocyte Activation Gene 3 Protein
- OX40 Ligand
- Programmed Cell Death 1 Ligand 2 Protein
3 drugs (2 approved, 1 experimental)
- Programmed Cell Death 1 Receptor
3 drugs (2 approved, 1 experimental)
- Receptors, OX40
Drugs by status
Phase 2 trials (3)