Chapter 4 - Endocrine, nutritional and metabolic diseases (E00-E89)»Disorders of other endocrine glands (E20-E35)»Multiple endocrine neoplasia [MEN] type IIB (E31.23)
E31.23
Multiple endocrine neoplasia [MEN] type IIB
Related indications (MeSH) (1)
Multiple Endocrine Neoplasia Type 2b5 drugs (4 approved, 1 experimental)
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.