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sucralose

Small moleculeexperimental

Sucralose is an artificial sweetener and sugar substitute. In the European Union, it is also known under the E number E955. It is produced by chlorination of sucrose, selectively replacing three of the hydroxy groups—in the C1 and C6 positions of the fructose portion and the C4 position of the glucose portion—to give a 1,6-dichloro-1,6-dideoxyfructose–4-chloro-4-deoxygalactose disaccharide. Sucralose is about 600 times sweeter than sucrose, 3 times as sweet as both aspartame and acesulfame potassium, and 2 times as sweet as sodium saccharin. — Wikipedia

Clinical trial activity

34 trials · 40 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
5
Phase 3
3
Phase 4
0

Earliest trial started Apr 1, 2007 (NCT00955747)

Timeline

2000s

  1. Jan 1, 2007

    Earliest Phase 3 Sponsor(trial)

2010s

  1. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2018

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

OC[C@@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H](O)[C@H]1Cl
Mol. weight
397.64 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1',4',6'-trichloro-1',4,6'-trideoxygalactosucrose
  • 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl-4-chloro-4-deoxy-alpha-d-galactopyranoside
  • alpha-d-galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-d-fructofuranosyl 4-chloro-4-deoxy-
  • splenda
  • splenda
  • splenda
  • sucralose
  • sucralose
  • sucralose
  • sucralose
  • trichlorogalactosucrose
  • trichlorogalacto-sucrose
  • trichlorosucrose

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06997133N/ASep 1, 2025Ciusss de L'Est de l'Île de Montréal
NCT07231133N/AMay 6, 2025Anderson Advanced Ingredients, Metropolitan University
NCT05852587Phase 1May 1, 2024Harvard University
NCT06094894N/AJun 1, 2023Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NCT05575687N/ANov 30, 2022Tate & Lyle, Wageningen University
NCT05279183N/AMar 17, 2022St. Claraspital Basel, University of Basel
NCT04633811N/AJan 1, 2022The University of Texas, Dallas, University of Alabama, Birmingham
NCT04713137N/AFeb 8, 2021St. Claraspital Basel, University of Basel
NCT04578431N/ANov 1, 2020Aarhus University
NCT04185662N/ADec 1, 2019Jiao Tong University, PuNan Hospital, Shanghai, ShiBei Hospital
NCT04182464N/ANov 1, 2019Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
NCT03436277Phase 2Dec 17, 2018University of Guadalajara
NCT03716609N/AOct 23, 2018Academia Sinica, Taiwan, Government of Taiwan, Institute of Biomedical Sciences, Academia Sinica, Taipei Veteran General hospital
NCT03407079Phase 2Apr 5, 2018National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03242434Phase 1Jan 29, 2018GlaxoSmithKline
NCT02800707N/AJan 3, 2017University of Minnesota
NCT03703141N/ASep 27, 2016Hospital General de México Dr. Eduardo Liceaga
NCT02569762N/AJul 1, 2016University of Manitoba
NCT05983328Phase 1May 10, 2016Sinew Pharma Inc.
NCT02745730N/AMar 31, 2016Leiden University, Unilever
Showing 20 of 34 trials
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Organizations

Research & Development (40)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranGovernment3312015
Yale UniversityAcademic/Hospital3312014
Braintree LaboratoriesFor profit2212008
Leiden UniversityAcademic/Hospital2012015
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government2122015
St. Claraspital BaselAcademic/Hospital2012021
UnileverFor profit2212015
University of BaselAcademic/Hospital2212021
Washington University in St. LouisAcademic/Hospital2212010
Aarhus UniversityAcademic/Hospital1112020
Academia Sinica, TaiwanAcademic/Hospital1112018
Anderson Advanced IngredientsFor profit1012025
Chang Gung UniversityAcademic/Hospital1012015
Ciusss de L'Est de l'Île de MontréalAcademic/Hospital1112025
GlaxoSmithKlineFor profit1112018
Government of TaiwanGovernment1012018
Harvard UniversityAcademic/Hospital1112024
Hospital General de México Dr. Eduardo LiceagaAcademic/Hospital1112016
Institute of Biomedical Sciences, Academia SinicaAcademic/Hospital1012018
Jiao Tong UniversityAcademic/Hospital1112019
40 organizations
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