bacillus subtilis
Bacillus subtilis, known also as the hay bacillus or grass bacillus, is a gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants, humans and marine sponges. As a member of the genus Bacillus, B. subtilis is rod-shaped, and can form a tough, protective endospore, allowing it to tolerate extreme environmental conditions. B. subtilis has historically been classified as an obligate aerobe, though evidence exists that it is a facultative anaerobe. B. subtilis is considered the best studied Gram-positive bacterium and a model organism to study bacterial chromosome replication and cell differentiation. It is one of the bacterial champions in secreted enzyme production and used on an industrial scale by biotechnology companies. — Wikipedia
Clinical trial activity
30 trials · 40 clinical orgs · 0 marketing orgs
Earliest trial started Jul 1, 2012 (NCT01802151)
Timeline
Indications
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBacillus subtilis ↗
Also known as
- bacillus subtilis
- bacillus subtilis
- bacillus subtilis mb40
- bacillus subtilis var natto dc-15
- b. subtilis r0179
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07123207 | N/A | Aug 4, 2025 | Central South University, Jiao Tong University |
| NCT06612411 | Early Phase 1 (Phase 1) | Jun 1, 2024 | Jinlin University |
| NCT06371950 | N/A | May 1, 2024 | University of Western Ontario |
| NCT06292546 | N/A | Jan 31, 2024 | Fudan University |
| NCT05929599 | N/A | Jul 5, 2023 | Anabio, National Children's Hospital, Vietnam |
| NCT07065942 | N/A | Jul 1, 2023 | Beijing Huaxin Hospital, Capital Medical University, Chinese Academy of Medical Sciences, Peking University |
| NCT06487975 | N/A | May 2, 2023 | NHS Lothian, Protexin, University of Edinburgh, University of Stavanger |
| NCT05776940 | Phase 3 | Mar 31, 2023 | Air Force Military Medical University, China |
| NCT05999955 | N/A | Dec 29, 2022 | Huro Biotech Joint Stock Company, Thai Binh University of Medicine and Pharmacy, Vietstar Biomedical Research |
| NCT05984004 | N/A | Sep 26, 2022 | Huro Biotech Joint Stock Company, Thai Binh University of Medicine and Pharmacy |
| NCT05403398 | N/A | Jun 30, 2022 | Lesaffre International, NIZO Food Research |
| NCT05804123 | N/A | Oct 28, 2021 | Anabio, Thai Binh University of Medicine and Pharmacy |
| NCT05750433 | N/A | Oct 1, 2021 | Colorado State University |
| NCT05239923 | N/A | Aug 28, 2021 | — |
| NCT05004454 | N/A | Jul 19, 2021 | BIO-CAT Microbials, LLC, Biofortis |
| NCT05057923 | N/A | Jul 10, 2021 | DreamTec Cytokine Limited |
| NCT05158855 | N/A | Jun 1, 2021 | DreamTec Cytokine Limited, Hong Kong Metropolitan University |
| NCT05378022 | N/A | Dec 21, 2020 | National Children's Hospital, Vietnam, Vietnam National Children's Hospital |
| NCT04489810 | N/A | Sep 19, 2020 | Atlantia Food Clinical Trials, Deerland Enzymes, Teagasc |
| NCT04489836 | N/A | Aug 31, 2020 | Atlantia Food Clinical Trials, Deerland Enzymes, Teagasc |
Organizations
Research & Development (40)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Deerland Enzymes | For profit | 4 | 3 | 1 | 2016 |
| National Children's Hospital, Vietnam | Academic/Hospital | 3 | 3 | 1 | 2020 |
| Thai Binh University of Medicine and Pharmacy | Academic/Hospital | 3 | 0 | 1 | 2021 |
| Anabio | For profit | 2 | 1 | 1 | 2021 |
| Atlantia Food Clinical Trials | For profit | 2 | 0 | 1 | 2020 |
| BIO-CAT Microbials, LLC | For profit | 2 | 2 | 2 | 2016 |
| DreamTec Cytokine Limited | For profit | 2 | 2 | 1 | 2021 |
| Huro Biotech Joint Stock Company | For profit | 2 | 2 | 1 | 2022 |
| Lallemand SAS | For profit | 2 | 0 | 2 | 2012 |
| Teagasc | Government | 2 | 0 | 1 | 2020 |
| University of Florida | Academic/Hospital | 2 | 2 | 2 | 2012 |
| Vietnam National Children's Hospital | Academic/Hospital | 2 | 0 | 1 | 2020 |
| Air Force Military Medical University, China | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Beijing Huaxin Hospital | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Biofortis | For profit | 1 | 0 | 1 | 2021 |
| Capital Medical University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Central South University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Colorado State University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Fudan University | Academic/Hospital | 1 | 1 | 1 | 2024 |