sodium phytate
Phytic acid is a major phosphorus storage compound of most seeds and cereal grains. It has the strong ability to chelate multivalent metal ions, especially zinc, calcium, and iron. Phytic acid is also considered to be a natural antioxidant and is suggested to have potential functions of reducing lipid peroxidation and as a preservative in foods. Clathrin-associated adaprot complex AP-2 has it been suggested may act as one of the receptor sites for Phytic acid. Both in vivo and in vitro experiments have demonstrated striking anticancer (preventive as well as therapeutic) effects of Phytic acid. — NCATS
Clinical trial activity
6 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Aug 1, 2009 (NCT01000233)
Timeline
2000s
- Jan 1, 2009
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetCHELATING AGENT
chelating agent
Chemistry & pharmacology
SMILES
OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O- Mol. weight
- 660.0353 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATS7IGF0S7R8I ↗
- ChEMBLCHEMBL1233511 ↗
Also known as
- e391
- e391
- fytic acid
- fytic acid
- fytic acid
- fytic acid
- inositol hexaphosphate
- insadol
- phyliance
- phytate
- phytate
- phytic acid
- phytic acid
- phytic acid
- phytic acid
- phytic acid
- sodium phytate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03826277 | N/A | Feb 28, 2019 | Higher School of Applied Sciences (VIST) |
| NCT04238429 | N/A | May 7, 2018 | Sun Yat-Sen University |
| NCT03030703 | N/A | Nov 11, 2016 | American Academy of Nurse Practitioners, Kansas State University, United States Department of Agriculture |
| NCT02751320 | N/A | Feb 1, 2016 | GlaxoSmithKline |
| NCT01499225 | Phase 2 | Dec 1, 2011 | Yuhan Pharmaceutical Company |
| NCT01000233 | Phase 2/Phase 3 (Phase 3) | Aug 1, 2009 | BIOMED, Hospital Universitari Son Dureta |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| American Academy of Nurse Practitioners | Academic/Hospital | 1 | 0 | 1 | 2016 |
| BIOMED | Academic/Hospital | 1 | 0 | 1 | 2009 |
| GlaxoSmithKline | For profit | 1 | 1 | 1 | 2016 |
| Higher School of Applied Sciences (VIST) | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Hospital Universitari Son Dureta | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Kansas State University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| United States Department of Agriculture | Government | 1 | 0 | 1 | 2016 |
| Yuhan Pharmaceutical Company | For profit | 1 | 1 | 1 | 2011 |