live, attenuated, dengue serotype 1, 2, 3, 4 virus
Vaccineexperimental
Dengue vaccine is a vaccine used to prevent dengue fever in humans. Development of dengue vaccines began in the 1920s but was hindered by the need to create immunity against all four dengue serotypes. As of 2023, there are two commercially available vaccines, sold under the brand names Dengvaxia and Qdenga. — Wikipedia
Clinical trial activity
41 trials · 21 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
34
Phase 3
20
Phase 4
0
Earliest trial started Aug 1, 2003 (NCT00384670)
Timeline
Indications
Studied for
- Antiphospholipid Syndrome · Phase 3
- Arthritis, Juvenile · Phase 3
- Arthritis, Psoriatic · Phase 3
- Arthritis, Rheumatoid · Phase 3
- Axial Spondyloarthritis · Phase 3
- Chikungunya Fever · Phase 3
- Dengue · Phase 3
- Dengue Virus · Phase 1
- Granulomatosis with Polyangiitis · Phase 3
- Healthy Volunteers · Phase 3
- Lupus Erythematosus, Systemic · Phase 3
- Microscopic Polyangiitis · Phase 3
- Sclerosis · Phase 3
- Severe Dengue · Phase 3
- Takayasu Arteritis · Phase 3
- Yellow Fever · Phase 3
Mechanism of action
- Dengue virusImmunity, active
Dengue virus immunity, active
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDengue vaccine ↗
- WikipediaDengue fever vaccine ↗
Also known as
- dengue 1,2,3,4 (attenuated) vaccine
- dengue fever vaccine
- live, attenuated, dengue serotype 1, 2, 3, 4 virus
- live, attenuated, recombinant dengue serotype 1, 2, 3, 4 virus
- live attenuated tetravalent dengue fever vaccine
- live attenuated tetravalent dengue vaccine
- recombinant live attenuated trivalent dengue vaccine
- tetravalent dengue vaccine
- tetravalent dengue vaccine
- tetravalent dengue vaccine candidate
- tetravalent dengue vaccine (tvdv)
- tetravalent live attenuated dengue vaccine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07087912 | Phase 3 | Jan 1, 2026 | Butantan Institute, University of Sao Paulo |
| NCT06891950 | Phase 3 | Nov 30, 2025 | Butantan Institute, Fundação Butantan |
| NCT07047521 | Phase 3 | Nov 7, 2025 | Takeda |
| NCT06973772 | Phase 3 | Aug 31, 2025 | Butantan Institute |
| NCT06665035 | Phase 3 | Apr 30, 2025 | Takeda |
| NCT06579755 | Phase 3 | Mar 17, 2025 | Takeda |
| NCT06741683 | Phase 2/Phase 3 (Phase 3) | Jan 31, 2025 | Takeda |
| NCT06060067 | Phase 3 | Feb 8, 2024 | Takeda |
| NCT03999996 | Phase 3 | Oct 1, 2019 | Takeda |
| NCT03771963 | Phase 3 | Mar 28, 2019 | Takeda |
| NCT03746015 | Phase 2 | Dec 28, 2018 | Takeda |
| NCT03342898 | Phase 3 | Feb 28, 2018 | Takeda |
| NCT03341637 | Phase 3 | Dec 14, 2017 | Takeda |
| NCT02948829 | Phase 2 | Apr 3, 2017 | Takeda |
| NCT02747927 | Phase 3 | Sep 7, 2016 | Takeda |
| NCT02406729 | Phase 3 | Feb 1, 2016 | Butantan Institute |
| NCT02433652 | Phase 1 | Sep 1, 2015 | Johns Hopkins University, National Institute of Allergy and Infectious Diseases (NIAID), University of Vermont |
| NCT02425098 | Phase 2 | Jun 3, 2015 | Takeda |
| NCT02302066 | Phase 2 | Dec 1, 2014 | Takeda |
| NCT02193087 | Phase 2 | Jul 1, 2014 | Takeda |
Showing 20 of 41 trials
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Organizations
Research & Development (21)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Takeda | For profit | 18 | 18 | 3 | 2012 |
| Sanofi | For profit | 11 | 11 | 2 | 2010 |
| Sanofi-Aventis | For profit | 6 | 0 | 2 | 2010 |
| Butantan Institute | Academic/Hospital | 5 | 4 | 2 | 2013 |
| United States Army | Government | 5 | 4 | 2 | 2003 |
| GlaxoSmithKline | For profit | 4 | 1 | 1 | 2003 |
| Government of Thailand | Government | 2 | 0 | 1 | 2003 |
| Inviragen | For profit | 2 | 1 | 1 | 2010 |
| Banco Nacional de Desenvolvimento Economico e Social | Government | 1 | 0 | 1 | 2013 |
| Butantan Foundation | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Department of Defense | Government | 1 | 0 | 1 | 2013 |
| Fundação Butantan | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Fundação de Amparo à Pesquisa do Estado de São Paulo | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Johns Hopkins University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 2015 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2013 |
| United States Navy | Government | 1 | 0 | 1 | 2011 |
| Universidad de Antioquia | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Sao Paulo | Academic/Hospital | 1 | 1 | 1 | 2026 |
| University of Vermont | Academic/Hospital | 1 | 0 | 1 | 2015 |
21 organizations
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