evinacumab
Trade name: EVKEEZA
mAbapprovedOrphan Drug FDABreakthrough Therapy FDA
Approved
Feb 11, 2021
Evinacumab, sold under the brand name Evkeeza, is a monoclonal antibody medication for the treatment of homozygous familial hypercholesterolemia (HoFH). — Wikipedia
Clinical trial activity
13 trials · 3 clinical orgs · 1 marketing orgs
Phase 1
3
Phase 2
8
Phase 3
3
Phase 4
1
Earliest trial started Dec 1, 2012 (NCT01749878)
Timeline
2010s
Indications
Mechanism of action
- Angiopoietin-related protein 3ANTAGONIST
ANGPTL3
- Angiopoietin-related protein 3INHIBITOR
ANGPTL3 inhibitor
Approval history
- approvedPriority reviewBreakthroughFeb 11, 2021
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
- Multi-specific
- No
Oral
No
Parenteral
Yes
Topical
No
First in class
Sources
- WikipediaEvinacumab ↗
- ChEMBLCHEMBL3545191 ↗
Also known as
- evinacumab
- evinacumab
- regn1500
- regn-1500
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07271186 | Phase 2 | Dec 9, 2025 | Regeneron |
| NCT05611528 | Phase 4 | Dec 31, 2022 | Ecogene 21, Ultragenyx Inc. |
| NCT04863014 | Phase 2 | Jul 12, 2021 | Regeneron |
| NCT04233918 | Phase 3 | Jun 5, 2020 | Regeneron |
| NCT03452228 | Phase 2 | Jun 7, 2018 | Regeneron |
| NCT03409744 | Phase 3 | Mar 13, 2018 | Regeneron |
| NCT03399786 | Phase 3 | Jan 18, 2018 | Regeneron |
| NCT03175367 | Phase 2 | Aug 28, 2017 | Regeneron |
| NCT03146416 | Phase 1 | May 1, 2017 | Regeneron |
| NCT02265952 | Phase 2 | Oct 1, 2014 | Regeneron |
| NCT02107872 | Phase 1 | Apr 1, 2014 | Regeneron |
| NCT01749878 | Phase 1 | Dec 1, 2012 | Regeneron |
| NCT06500598 | N/A | — | Regeneron |
Showing 13 of 13 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Regeneron | For profit | 12 | 12 | 4 | 2012 |
| Ecogene 21 | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Ultragenyx Inc. | For profit | 1 | 0 | 1 | 2022 |
3 organizations
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