autologous keratinocytes
Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. Basal cells in the basal layer of the skin are sometimes referred to as basal keratinocytes. Keratinocytes form a barrier against environmental damage by heat, UV radiation, water loss, pathogenic bacteria, fungi, parasites, and viruses. A number of structural proteins, enzymes, lipids, and antimicrobial peptides contribute to maintain the important barrier function of the skin. Keratinocytes differentiate from epidermal stem cells in the lower part of the epidermis and migrate towards the surface, finally becoming corneocytes and eventually being shed, which happens every 40 to 56 days in humans. — Wikipedia
Clinical trial activity
4 trials · 7 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2005 (NCT00856934)
Timeline
Indications
Studied for
Mechanism of action
- KeratinocytesTissue restoration
tissue restoration - keratinocytes
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaKeratinocyte ↗
Also known as
- autologous cultured keratinocyte
- autologous keratinocytes
- keratinocytes
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04485962 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2017 | Belarusian Medical Academy of Post-Graduate Education, Belarusian State Medical University, National Academy of Sciences of Belarus |
| NCT00832156 | Phase 3 | Jun 1, 2008 | Association of Dutch Burn Centres |
| NCT00978705 | Phase 3 | Nov 1, 2007 | Hangang Sacred Heart Hospital, Modern Cell and Tissue Technology |
| NCT00856934 | Phase 1 | Jun 1, 2005 | University of Lausanne |
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Association of Dutch Burn Centres | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Belarusian Medical Academy of Post-Graduate Education | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Belarusian State Medical University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Hangang Sacred Heart Hospital | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Modern Cell and Tissue Technology | Academic/Hospital | 1 | 1 | 1 | 2007 |
| National Academy of Sciences of Belarus | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Lausanne | Academic/Hospital | 1 | 1 | 1 | 2005 |