autologous keratinocytes

Cell therapyexperimental

Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. Basal cells in the basal layer of the skin are sometimes referred to as basal keratinocytes. Keratinocytes form a barrier against environmental damage by heat, UV radiation, water loss, pathogenic bacteria, fungi, parasites, and viruses. A number of structural proteins, enzymes, lipids, and antimicrobial peptides contribute to maintain the important barrier function of the skin. Keratinocytes differentiate from epidermal stem cells in the lower part of the epidermis and migrate towards the surface, finally becoming corneocytes and eventually being shed, which happens every 40 to 56 days in humans. — Wikipedia

Clinical trial activity

4 trials · 7 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
3
Phase 3
2
Phase 4
0

Earliest trial started Jun 1, 2005 (NCT00856934)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

  • KeratinocytesTissue restoration

    tissue restoration - keratinocytes

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • autologous cultured keratinocyte
  • autologous keratinocytes
  • keratinocytes

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT04485962Phase 1/Phase 2 (Phase 2)Jan 1, 2017Belarusian Medical Academy of Post-Graduate Education, Belarusian State Medical University, National Academy of Sciences of Belarus
NCT00832156Phase 3Jun 1, 2008Association of Dutch Burn Centres
NCT00978705Phase 3Nov 1, 2007Hangang Sacred Heart Hospital, Modern Cell and Tissue Technology
NCT00856934Phase 1Jun 1, 2005University of Lausanne
Showing 4 of 4 trials
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Organizations

Research & Development (7)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Association of Dutch Burn CentresAcademic/Hospital1112008
Belarusian Medical Academy of Post-Graduate EducationAcademic/Hospital1012017
Belarusian State Medical UniversityAcademic/Hospital1012017
Hangang Sacred Heart HospitalAcademic/Hospital1012007
Modern Cell and Tissue TechnologyAcademic/Hospital1112007
National Academy of Sciences of BelarusAcademic/Hospital1112017
University of LausanneAcademic/Hospital1112005
7 organizations
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