calcium propionate
Calcium propionate (E282) is a preservative, antimould and antirope agent. Calcium propionate has been widely used as a preservative in bakery and in bread. The addition of 0.3 % calcium propionate prolonged the shelf-life of salt reduced bread to 10-12 days. It is sometimes not carefully used, or a high concentration is added to preserve products. High consumption of calcium propionate can lead to several health problems. Calcium propionate is used to prevent milk fever in cows and as a feed supplement. It is considered to be safe and effective treatment given for one or two days to prevent milk fever and/or to support treatment of milk fever. Calcium propionate is generally recognized as safe by FDA when used in accordance with good manufacturing or feeding practice. — NCATS
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Earliest trial started Aug 1, 2013 (NCT01889446)
Timeline
2010s
- Jan 1, 2017
Earliest Phase 2 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Pyruvate:ferredoxin oxidoreductaseINHIBITOR
PFOR inhibitor
Chemistry & pharmacology
SMILES
[Ca++].CCC([O-])=O.CCC([O-])=O- Mol. weight
- 186.219 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCalcium propanoate ↗
- NCATS8AI80040KW ↗
Also known as
- calcium propionate
- calcium propionate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04788680 | N/A | Mar 31, 2021 | University of Vienna |
| NCT04236713 | N/A | Jan 21, 2020 | McMaster University |
| NCT04019951 | N/A | Jul 31, 2019 | DSM, Glycemic Index Laboratories, Inc |
| NCT03590496 | Phase 2 | Nov 21, 2017 | Humboldt University |
| NCT01889446 | N/A | Aug 1, 2013 | Harvard University |
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| DSM | For profit | 1 | 1 | 1 | 2019 |
| Glycemic Index Laboratories, Inc | For profit | 1 | 0 | 1 | 2019 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Humboldt University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| McMaster University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| University of Vienna | Academic/Hospital | 1 | 1 | 1 | 2021 |