apatorsen
Nucleic acidexperimental
Clinical trial activity
9 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
7
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2007 (NCT00487786)
Timeline
Indications
Studied for
Mechanism of action
- Heat shock protein beta-1ANTISENSE INHIBITOR
HSPB1 antisense inhibitor
- Heat shock protein beta-1 (HSP27) mRNAANTISENSE INHIBITOR
Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3039556 ↗
Also known as
- apatorsen
- apatorsen
- apatorsen
- apatorsen
- ogx-427
- ogx-427
- ogx-427
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02423590 | Phase 2 | Jun 1, 2014 | OncoGenex Technologies, University of London |
| NCT01844817 | Phase 2 | Sep 1, 2013 | OncoGenex Technologies, SCRI Development Innovations |
| NCT01829113 | Phase 2 | Jul 1, 2013 | OncoGenex Technologies, SCRI Development Innovations |
| NCT01780545 | Phase 2 | Apr 1, 2013 | Hoosier Cancer Research Network, Johns Hopkins University, OncoGenex Technologies |
| NCT01681433 | Phase 2 | Dec 1, 2012 | Hoosier Cancer Research Network, Indiana University, OncoGenex Technologies |
| NCT01454089 | Phase 2 | Oct 1, 2011 | Columbia University, OncoGenex Technologies, Pharmaceutical Research Associates, Inc. (PRA) |
| NCT01120470 | Phase 2 | Sep 1, 2010 | British Columbia Cancer Agency, OncoGenex Technologies |
| NCT00959868 | Phase 1 | Jul 1, 2009 | Canadian Cancer Trials Group, University of British Columbia, Vancouver Coastal Health |
| NCT00487786 | Phase 1 | Jun 1, 2007 | OncoGenex Technologies, University of British Columbia |
Showing 9 of 9 trials
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Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| OncoGenex Technologies | For profit | 8 | 2 | 2 | 2007 |
| Hoosier Cancer Research Network | Academic/Hospital | 2 | 0 | 1 | 2012 |
| SCRI Development Innovations | For profit | 2 | 2 | 1 | 2013 |
| University of British Columbia | Academic/Hospital | 2 | 0 | 1 | 2007 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Canadian Cancer Trials Group | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Columbia University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Indiana University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Johns Hopkins University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | 1 | 0 | 1 | 2011 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Vancouver Coastal Health | Academic/Hospital | 1 | 1 | 1 | 2009 |
12 organizations
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