zmapp

Botanicalexperimental

ZMapp is an experimental biopharmaceutical medication comprising three chimeric monoclonal antibodies under development as a treatment for Ebola virus disease. Two of the three components were originally developed at the Public Health Agency of Canada's National Microbiology Laboratory (NML), and the third at the U.S. Army Medical Research Institute of Infectious Diseases; the cocktail was optimized by Gary Kobinger, a research scientist at the NML and underwent further development under license by Mapp Biopharmaceutical. ZMapp was first used on humans during the Western African Ebola virus epidemic, having only been previously tested on animals and not yet subjected to a randomized controlled trial. The National Institutes of Health (NIH) ran a clinical trial starting in January 2015 with subjects from Sierra Leone, Guinea, and Liberia aiming to enroll 200 people, but the epidemic waned and the trial closed early, leaving it too statistically underpowered to give a meaningful result about whether ZMapp worked. — Wikipedia

Clinical trial activity

3 trials · 5 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
1
Phase 3
1
Phase 4
0

Earliest trial started Feb 11, 2015 (NCT02363322)

Timeline

2010s

  1. Jan 1, 2015

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2018

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

  • EbolavirusImmunity, passive

    Ebolavirus immunity, passive

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • zmapp

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT03719586Phase 2/Phase 3 (Phase 3)Nov 20, 2018National Institute of Allergy and Infectious Diseases (NIAID)
NCT02389192Phase 1Mar 9, 2015National Institute of Allergy and Infectious Diseases (NIAID)
NCT02363322Phase 1/Phase 2 (Phase 2)Feb 11, 2015Government of Liberia, Government of Sierra Leone, Government of the Republic of Guinea, Institut National de la Santé Et de la Recherche Médicale, France, National Institute of Allergy and Infectious Diseases (NIAID)
Showing 3 of 3 trials
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Organizations

Research & Development (5)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Institute of Allergy and Infectious Diseases (NIAID)Government3332015
Government of LiberiaGovernment1012015
Government of Sierra LeoneGovernment1012015
Government of the Republic of GuineaGovernment1012015
Institut National de la Santé Et de la Recherche Médicale, FranceAcademic/Hospital1012015
5 organizations
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