zmapp
ZMapp is an experimental biopharmaceutical medication comprising three chimeric monoclonal antibodies under development as a treatment for Ebola virus disease. Two of the three components were originally developed at the Public Health Agency of Canada's National Microbiology Laboratory (NML), and the third at the U.S. Army Medical Research Institute of Infectious Diseases; the cocktail was optimized by Gary Kobinger, a research scientist at the NML and underwent further development under license by Mapp Biopharmaceutical. ZMapp was first used on humans during the Western African Ebola virus epidemic, having only been previously tested on animals and not yet subjected to a randomized controlled trial. The National Institutes of Health (NIH) ran a clinical trial starting in January 2015 with subjects from Sierra Leone, Guinea, and Liberia aiming to enroll 200 people, but the epidemic waned and the trial closed early, leaving it too statistically underpowered to give a meaningful result about whether ZMapp worked. — Wikipedia
Clinical trial activity
3 trials · 5 clinical orgs · 0 marketing orgs
Earliest trial started Feb 11, 2015 (NCT02363322)
Timeline
Indications
Mechanism of action
- EbolavirusImmunity, passive
Ebolavirus immunity, passive
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03719586 | Phase 2/Phase 3 (Phase 3) | Nov 20, 2018 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT02389192 | Phase 1 | Mar 9, 2015 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT02363322 | Phase 1/Phase 2 (Phase 2) | Feb 11, 2015 | Government of Liberia, Government of Sierra Leone, Government of the Republic of Guinea, Institut National de la Santé Et de la Recherche Médicale, France, National Institute of Allergy and Infectious Diseases (NIAID) |
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 3 | 3 | 3 | 2015 |
| Government of Liberia | Government | 1 | 0 | 1 | 2015 |
| Government of Sierra Leone | Government | 1 | 0 | 1 | 2015 |
| Government of the Republic of Guinea | Government | 1 | 0 | 1 | 2015 |
| Institut National de la Santé Et de la Recherche Médicale, France | Academic/Hospital | 1 | 0 | 1 | 2015 |