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zeaxanthin

Small moleculeexperimental

Zeaxanthin is one of the most common carotenoid alcohols found in nature. It is synthesized in plants and some micro-organisms. Lutein and Zeaxanthin are found in the macula of the human retina, as well as the human crystalline lens. They play a role in protection against age-related macular degeneration (ARMD) and cataract formation. The antioxidant properties of lutein and zeaxanthin together with ocular antioxidants (selenium, zinc, copper, vitamin A, C, E, etc.) inhibit free radical damage caused by light and oxygen. Zeaxanthin supplements are typically taken on the supposition of supporting eye health. It is is Generally Recognized As Safe by FDA. — NCATS

Clinical trial activity

29 trials · 37 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
10
Phase 3
6
Phase 4
0

Earliest trial started Sep 1, 2006 (NCT00345176)

Timeline

2000s

  1. Jan 1, 2006

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

CC(\C=C\C=C(C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C
Mol. weight
568.8714 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • zeaxanthin
  • zeaxanthin
  • zeaxanthin
  • zeaxanthine
  • zeaxanthine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06965426N/AJun 1, 2025InSight Eyecare, MacuHealth LP
NCT05794074N/AApr 1, 2023Assistance Publique - Hôpitaux de Paris
NCT05232409Phase 1Mar 31, 2022Valley Health System
NCT06358352N/AOct 1, 2021Mansoura University
NCT04499820N/AJun 26, 2020Centre Hospitalier Intercommunal Creteil, Laboratoires Thea
NCT03959592Phase 1/Phase 2 (Phase 2)Aug 31, 2019Duke University, Heidelberg Engineering GmbH, Industrial Orgánica S.A. de C.V., MacuHealth LP
NCT04071977Phase 2Aug 31, 2019University of Guadalajara
NCT03983525N/AJun 7, 2019University of California, Davis
NCT03866005N/AMay 1, 2019Sound Retina, ZeaVision, Inc.
NCT03702374Phase 3Sep 26, 2018Instituto Mexicano del Seguro Social, University of Guadalajara
NCT03919019N/AJan 18, 2018Fondazione G.B. Bietti, IRCCS
NCT04460365N/AOct 1, 2017Centre for Eye Research Ireland
NCT02200263N/ANov 1, 2014Clark Charitable Foundation Inc., Johns Hopkins University
NCT02113254N/AFeb 28, 2014University of Bordeaux
NCT01627977Phase 3Oct 31, 2012Federal University of Sao Paulo
NCT01621789Phase 3Jun 30, 2012Federal University of Sao Paulo
NCT02017418N/AFeb 1, 2012University of Georgia, ZeaVision, Inc.
NCT01404845N/ASep 1, 2011Affordance
NCT01778231N/AMar 1, 2011Queen's University, Belfast
NCT02062034Phase 2Feb 1, 2011Instituto Mexicano del Seguro Social, University of Guadalajara
Showing 20 of 29 trials
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Organizations

Research & Development (37)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of GuadalajaraAcademic/Hospital3322011
Federal University of Sao PauloAcademic/Hospital2212012
Friedrich Schiller UniversityAcademic/Hospital2212008
Instituto Mexicano del Seguro SocialGovernment2022011
Laboratoires TheaFor profit2022011
MacuHealth LPFor profit2022019
Peking UniversityAcademic/Hospital2222009
University of BordeauxAcademic/Hospital2222011
University of GeorgiaAcademic/Hospital2222009
University of LeipzigAcademic/Hospital2012008
ZeaVision, Inc.For profit2112012
AffordanceAcademic/Hospital1112011
Assistance Publique - Hôpitaux de ParisAcademic/Hospital1112023
Centre for Eye Research IrelandAcademic/Hospital1112017
Centre Hospitalier Intercommunal CreteilAcademic/Hospital1112020
Chrysantis, Inc.For profit1112007
Clark Charitable Foundation Inc.Academic/Hospital1012014
Department of Veteran AffairsGovernment1012007
Duke UniversityAcademic/Hospital1112019
Fondazione G.B. Bietti, IRCCSAcademic/Hospital1112018
37 organizations
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