vs-4718
Small moleculeexperimental
Clinical trial activity
3 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2013 (NCT01849744)
Timeline
2010s
- Jan 1, 2013
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Focal adhesion kinase 1INHIBITOR
PTK2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F- Mol. weight
- 501.51 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3544933 ↗
- ChEMBLCHEMBL3040440 ↗
Also known as
- pnd1186
- pnd 1186
- pnd-1186
- vs-4718
- vs-4718
- vs-4718
- vs-4718
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02651727 | Phase 1 | Sep 1, 2015 | Verastem, Inc. |
| NCT02215629 | Phase 1 | Aug 7, 2014 | Verastem, Inc. |
| NCT01849744 | Phase 1 | Jun 1, 2013 | Verastem, Inc. |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Verastem, Inc. | For profit | 3 | 3 | 1 | 2013 |
1 organizations
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