antimony

Small moleculeexperimental

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK. — NCATS

Clinical trial activity

9 trials · 15 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Feb 1, 2004 (NCT00973128)

Timeline

2000s

Jan 1, 2004
Earliest Phase 2 Sponsor(trial)

2010s

Jan 1, 2017
Earliest Phase 3 Sponsor(trial)
Jan 1, 2019
Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Schistosomiasis

Studied for

Mechanism of action

UnclearUnclear
Unclear unclear

Chemistry & pharmacology

Loading structure…

SMILES

[Sb+3]

Mol. weight: 121.76 g/mol
Chirality: Achiral Molecule
Inorganic: Yes
Polymer: No

Oral

Parenteral

Topical

Sources

Also known as

antimony
antimony
antimony
antimony cation (5+)
antimony cation (5+)
antimony oxide
antimony oxide
antimony oxide
antimony pentasulfide
antimony pentasulfide
antimony pentasulfide
antimony pentasulfide
antimony red
antimony sodium gluconate
antimony sodium gluconate
antimony tetroxide
antimony (v) derivative of sodium gluconate
antimony (v) derivative of sodium gluconate
pentavalent antimony
pentavalent antimony
pentavalent antimony
sb5+
sb5+
sodium antimony gluconate
sodium antimony gluconate

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT04799236	Phase 3	Apr 1, 2021	AB Foundation for Medical Research, Centro Nacional de Enfermedades Tropicales CENETROP, Fundacion Nacional de Dermatologia, Hospital Dermatológico de Jorochito
NCT06000514	Phase 1/Phase 2 (Phase 2)	Jan 17, 2019	Conselho Nacional de Desenvolvimento Científico e Tecnológico, Federal University of Bahia, Federal University of Minas Gerais, Oswaldo Cruz Foundation
NCT03023111	Phase 3	Mar 1, 2017	Federal University of Bahia, Instituto de Medicina Integral Professor Fernando Figueira, Oswaldo Cruz Foundation
NCT01300975	Phase 2	Jan 1, 2011	Fundacion Nacional de Dermatologia, Hospital Dermatológico de Jorochito, Proyecto OSCAR, The Alfred Berman Foundation for Medical Research, Universidad Mayor San Simón, Cochabamba, Bolivia.
NCT01138956	N/A	Apr 1, 2010	Federal University of Bahia
NCT00537953	Phase 2	Sep 28, 2007	AB Foundation for Medical Research, Cenetrop, Centro de Investigaciones Bioclínicas de la Fundación Fader
NCT01380301	Phase 2	Mar 1, 2007	AB Foundation for Medical Research, Foundation Fader
NCT00233545	Phase 2	Sep 1, 2005	AB Foundation for Medical Research
NCT00973128	Phase 2	Feb 1, 2004	Federal University of Bahia

Showing 9 of 9 trials

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Organizations

Research & Development (15)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
AB Foundation for Medical Research	Academic/Hospital	4	1	2	2005
Federal University of Bahia	Academic/Hospital	4	4	3	2004
Fundacion Nacional de Dermatologia	Academic/Hospital	2	2	2	2011
Hospital Dermatológico de Jorochito	Academic/Hospital	2	0	2	2011
Oswaldo Cruz Foundation	Academic/Hospital	2	0	2	2017
Cenetrop	Academic/Hospital	1	0	1	2007
Centro de Investigaciones Bioclínicas de la Fundación Fader	Academic/Hospital	1	1	1	2007
Centro Nacional de Enfermedades Tropicales CENETROP	Academic/Hospital	1	0	1	2021
Conselho Nacional de Desenvolvimento Científico e Tecnológico	Government	1	0	1	2019
Federal University of Minas Gerais	Academic/Hospital	1	0	1	2019
Foundation Fader	Academic/Hospital	1	1	1	2007
Instituto de Medicina Integral Professor Fernando Figueira	Academic/Hospital	1	0	1	2017
Proyecto OSCAR	Academic/Hospital	1	0	1	2011
The Alfred Berman Foundation for Medical Research	Academic/Hospital	1	0	1	2011
Universidad Mayor San Simón, Cochabamba, Bolivia.	Academic/Hospital	1	0	1	2011

15 organizations

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