triptolide
Small moleculeexperimental
Triptolide is a diterpenoid epoxide which is produced by the thunder god vine, Tripterygium wilfordii. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties and severe toxicity limit its therapeutic potential. Consequently, a synthetic water-soluble prodrug, minnelide, is being studied clinically instead. — Wikipedia
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
3
Phase 4
0
Earliest trial started Jan 1, 2013 (NCT01817283)
Timeline
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)[C@]12O[C@H]1[C@@H]1O[C@]13[C@]1(O[C@H]1C[C@H]1C4=C(CC[C@@]13C)C(=O)OC4)[C@@H]2O- Mol. weight
- 360.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTriptolide ↗
- ChEMBLCHEMBL463763 ↗
Also known as
- pg490
- triplitode
- triptolide
- triptolide
- triptolide
- triptolide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03403569 | Phase 3 | Aug 1, 2018 | Chinese Academy of Medical Sciences |
| NCT02219672 | Phase 3 | Jul 1, 2014 | Government of China, Tsinghua University |
| NCT02115659 | Phase 3 | Apr 1, 2014 | Second Military Medical University |
| NCT01817283 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2013 | Peking University, Tsinghua University |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Tsinghua University | Academic/Hospital | 2 | 1 | 2 | 2013 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Government of China | Government | 1 | 0 | 1 | 2014 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Second Military Medical University | Government | 1 | 1 | 1 | 2014 |
5 organizations
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