tirasemtiv
Small moleculeexperimental
Clinical trial activity
8 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
8
Phase 3
2
Phase 4
0
Earliest trial started Mar 1, 2010 (NCT01089010)
Timeline
Indications
Mechanism of action
- Fast skeletal troponin complexACTIVATOR
Fast skeletal troponin complex activator
Chemistry & pharmacology
Loading structure…
SMILES
C#Cc1cnc2nc(O)n(C(CC)CC)c2n1- Mol. weight
- 230.27 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3039529 ↗
Also known as
- ck-2017357
- ck-2017357
- ck-2017357
- ck-2017357
- tirasemtiv
- tirasemtiv
- tirasemtiv
- tirasemtiv
- tirasemtiv
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02936635 | Phase 3 | Oct 1, 2016 | Cytokinetics |
| NCT02496767 | Phase 3 | Aug 1, 2015 | Cytokinetics |
| NCT01709149 | Phase 2 | Oct 1, 2012 | Cytokinetics, State University of New York, Syracuse |
| NCT01486849 | Phase 2 | Nov 1, 2011 | Cytokinetics, State University of New York, Syracuse |
| NCT01378676 | Phase 2 | Jun 1, 2011 | Cytokinetics, State University of New York, Syracuse |
| NCT01268280 | Phase 2 | Dec 1, 2010 | Cytokinetics, National Institute of Neurological Disorders and Stroke (NINDS) |
| NCT01131013 | Phase 2 | May 1, 2010 | Colorado Prevention Center, Cytokinetics, University of Minnesota |
| NCT01089010 | Phase 2 | Mar 1, 2010 | Cytokinetics, State University of New York, Syracuse |
Showing 8 of 8 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cytokinetics | For profit | 8 | 8 | 2 | 2010 |
| State University of New York, Syracuse | Academic/Hospital | 4 | 0 | 1 | 2010 |
| Colorado Prevention Center | Academic/Hospital | 1 | 0 | 1 | 2010 |
| National Institute of Neurological Disorders and Stroke (NINDS) | Government | 1 | 0 | 1 | 2010 |
| University of Minnesota | Academic/Hospital | 1 | 0 | 1 | 2010 |
5 organizations
Page 1 / 1