tigatuzumab
mAbexperimental
Tigatuzumab (CS-1008) is a monoclonal antibody for the treatment of cancer. As of October 2009, a clinical trial for the treatment of pancreatic cancer, Phase II trials for colorectal cancer, non-small cell lung cancer, and ovarian cancer have been completed. — Wikipedia
Clinical trial activity
9 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
6
Phase 3
0
Phase 4
0
Earliest trial started Apr 28, 2006 (NCT00320827)
Timeline
Indications
Studied for
Mechanism of action
TNFRSF10B agonist
Mimics the natural receptor ligand TRAIL and binds to TRAIL-R2 (without crosslinking), activating signal transduction pathways that may result in tumor cell apoptosis and a reduction in tumor growth.
TNFRSF10B inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTigatuzumab ↗
- ChEMBLCHEMBL1743080 ↗
Also known as
- cs-1008
- cs-1008
- cs-1008
- cs-1008
- tigatuzumab
- tigatuzumab
- tigatuzumab
- tra-8
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01307891 | Phase 2 | Mar 1, 2011 | Daiichi Sankyo, Susan G. Komen Breast Cancer Foundation, Triple Negative Breast Cancer Foundation, University of Alabama, Birmingham |
| NCT01220999 | Phase 1 | Oct 1, 2010 | Austin Health, Daiichi Sankyo, Ludwig Institute for Cancer Research |
| NCT01124630 | Phase 1 | May 1, 2010 | Daiichi Sankyo |
| NCT01033240 | Phase 2 | Mar 1, 2010 | Daiichi Sankyo |
| NCT00945191 | Phase 2 | Sep 1, 2009 | Daiichi Sankyo |
| NCT00969033 | Phase 2 | Jul 1, 2009 | Daiichi Sankyo |
| NCT00991796 | Phase 2 | Jun 1, 2009 | Daiichi Sankyo |
| NCT00521404 | Phase 2 | Aug 1, 2007 | Daiichi Sankyo |
| NCT00320827 | Phase 1 | Apr 28, 2006 | Daiichi Sankyo |
Showing 9 of 9 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Daiichi Sankyo | For profit | 9 | 7 | 2 | 2006 |
| Austin Health | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Ludwig Institute for Cancer Research | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Susan G. Komen Breast Cancer Foundation | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Triple Negative Breast Cancer Foundation | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Alabama, Birmingham | Academic/Hospital | 1 | 1 | 1 | 2011 |
6 organizations
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