thyrotropin alfa
Trade name: thyrogen
Recombinant proteinapprovedImaging agentOrphan Drug FDA
Approved
Nov 30, 1998
Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid. — Wikipedia
Clinical trial activity
6 trials · 6 clinical orgs · 1 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
2
Phase 4
1
Earliest trial started Dec 1, 1997 (NCT00001730)
Timeline
1990s
Indications
Mechanism of action
- Thyrotropin subunit betaSupplementation
TSHB supplementation
Approval history
- approvedNov 30, 1998
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
- Multi-specific
- No
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaThyroid-stimulating hormone ↗
- NCATSAVX3D5A4LM ↗
- ChEMBLCHEMBL1201533 ↗
Also known as
- thyrogen
- thyrogen
- thyrogen
- thyrotropin alfa
- thyrotropin alfa
- thyrotropin alfa
- thyrotropin alfa
- thyrotropin stimulated hormone
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03841617 | Phase 2 | Jul 5, 2019 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| NCT03276988 | Phase 1/Phase 2 (Phase 2) | Sep 11, 2017 | Catholic University of Korea, Genexine, Inc., Symyoo |
| NCT01403324 | N/A | Sep 1, 2011 | Institut Gustave Roussy |
| NCT00295763 | Phase 3 | May 1, 2006 | Genzyme |
| NCT00196729 | Phase 3 | Dec 1, 2001 | Genzyme |
| NCT00001730 | Phase 4 | Dec 1, 1997 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Showing 6 of 6 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Genzyme | For profit | 2 | 2 | 1 | 2001 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 2 | 2 | 2 | 1997 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Genexine, Inc. | For profit | 1 | 1 | 1 | 2017 |
| Institut Gustave Roussy | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Symyoo | For profit | 1 | 0 | 1 | 2017 |
6 organizations
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