thiopurine
Thiopurine is an analogue of a purine wherein a C=O/C-OH group has been replaced by a C=S/C-SH group. These organosulfur compounds are bioactive in beneficial and complicating manner. They interfere with purine biosynthesis. Thiopurine drugs antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders, and organ transplant recipients. Azathioprine is a prodrug. 6-Mercaptopurine is substrate for three enzyme]]s: thiopurine methyltransferase, xanthine oxidase (to give 6-thiouric acid], and hypoxanthine phosphoribosyltransferase. They are also substrates for nudix hydrolase 15. — Wikipedia
Clinical trial activity
4 trials · 8 clinical orgs · 0 marketing orgs
Earliest trial started Jul 1, 2016 (NCT02929706)
Timeline
No events for the selected filters.
Indications
Approved for
Mechanism of action
RAC1 inhibitor
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaThiopurine ↗
Also known as
- thiopurine
- thiopurine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07248644 | Phase 4 | Mar 1, 2026 | University of Chile |
| NCT05072782 | Phase 4 | Oct 15, 2021 | Celltrion, Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives (GETAID) |
| NCT03220841 | Phase 4 | Oct 9, 2017 | AbbVie, Australasian Gastro Intestinal Research Foundation (AGIRF), University of New South Wales |
| NCT02929706 | N/A | Jul 1, 2016 | Sun Yat-Sen University, Zhejiang University |
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| AbbVie | For profit | 1 | 0 | 1 | 2017 |
| Australasian Gastro Intestinal Research Foundation (AGIRF) | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Celltrion | For profit | 1 | 0 | 1 | 2021 |
| Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives (GETAID) | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Chile | Academic/Hospital | 1 | 1 | 1 | 2026 |
| University of New South Wales | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Zhejiang University | Academic/Hospital | 1 | 0 | 1 | 2016 |