terizidone
Small moleculeexperimental
Terizidone is a drug used in the treatment of tuberculosis. Terizidone is mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivative of cycloserine with bacteriostatic activity. — Wikipedia
Clinical trial activity
2 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
1
Phase 4
1
Earliest trial started Mar 1, 2003 (NCT00042289)
Timeline
2010s
- Jan 1, 2015
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- D-alanylalanine synthetaseINHIBITOR
ddl inhibitor
- Alanine racemaseINHIBITOR
alr inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C1NOCC1/N=C/c1ccc(/C=N/C2CONC2=O)cc1- Mol. weight
- 302.29 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTerizidone ↗
- ChEMBLCHEMBL2107553 ↗
Also known as
- 4,4'-(p-phenylenebis(methyleneimino))bis-3-isoxazolidone
- terazolidone
- terivalidin
- terivalidin
- terivalidine
- terizidon
- terizidon
- terizidone
- terizidone
- terizidone
- terizidone
- terizidone
- terizidone
- terizidone
- terizidone
- terizidone, calcium salt, (r-(r*,r*))-isomer
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02454205 | Phase 2/Phase 3 (Phase 3) | Oct 1, 2015 | Stellenbosch University, University of Cape Town, University of Limpopo, Walter Sisulu University |
| NCT00042289 | Phase 4 | Mar 1, 2003 | Boston University, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) |
Showing 2 of 2 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Boston University | Academic/Hospital | 1 | 0 | 1 | 2003 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 2003 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2003 |
| Stellenbosch University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of Cape Town | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Limpopo | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Walter Sisulu University | Academic/Hospital | 1 | 0 | 1 | 2015 |
7 organizations
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