Taribavirin
Small moleculeexperimental
Taribavirin is an antiviral drug in Phase III human trials, but not yet approved for pharmaceutical use. It is a prodrug of ribavirin, active against a number of DNA and RNA viruses. Taribavirin has better liver-targeting than ribavirin, and has a shorter life in the body due to less penetration and storage in red blood cells. It is expected eventually to be the drug of choice for viral hepatitis syndromes in which ribavirin is active. These include hepatitis C and perhaps also hepatitis B and yellow fever. — Wikipedia
Clinical trial activity
4 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
4
Phase 3
2
Phase 4
0
Earliest trial started Dec 1, 2003 (NCT00230958)
Timeline
Indications
Studied for
Mechanism of action
- Hepatitis C virusINHIBITOR
Hepatitis C virus inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
N=C(N)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1- Mol. weight
- 243.22 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL2111108 ↗
- WikipediaTaribavirin ↗
- ChEMBLCHEMBL2107375 ↗
Also known as
- taribavirin
- taribavirin
- taribavirin
- taribavirin
- taribavirin
- taribavirin
- taribavirin hcl
- taribavirin hcl
- taribavirin hcl
- taribavirin hydrochloride
- taribavirin hydrochloride
- taribavirin hydrochloride
- taribavirin hydrochloride
- viramidine
- viramidine
- viramidine
- viramidine
- viramidine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00446134 | Phase 2 | Mar 1, 2007 | Bausch Health Companies, Cedars-Sinai Medical Center |
| NCT00305383 | Phase 2 | Nov 1, 2005 | Bausch Health Companies |
| NCT00093093 | Phase 3 | Jun 1, 2004 | Bausch Health Companies |
| NCT00230958 | Phase 3 | Dec 1, 2003 | Bausch Health Companies |
Showing 4 of 4 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bausch Health Companies | For profit | 4 | 4 | 2 | 2003 |
| Cedars-Sinai Medical Center | Academic/Hospital | 1 | 0 | 1 | 2007 |
2 organizations
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