apelin
Peptideexperimental
Apelin is a peptide that in humans is encoded by the APLN gene. Apelin is one of two endogenous ligands for the G-protein-coupled APJ receptor that is expressed at the surface of some cell types. It is widely expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal glands, endothelium, and human plasma. — Wikipedia
Clinical trial activity
12 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2009 (NCT00901888)
Timeline
Indications
Mechanism of action
- Apelin receptorAGONIST
Apelin receptor agonist
- Apelin receptorINHIBITOR
APLNR inhibitor
Chemistry & pharmacology
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaApelin ↗
- ChEMBLCHEMBL4650373 ↗
Also known as
- apelin
- apelin
- apelin-13
- apelin-13
- apelin-13
- apelin-13 peptide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06277336 | N/A | Mar 1, 2024 | University of Basel |
| NCT03956576 | N/A | Aug 31, 2019 | Kidney Cancer UK, University of Edinburgh |
| NCT03449251 | Phase 2 | Mar 28, 2018 | AstraZeneca, University of Cambridge |
| NCT02724566 | Phase 1 | Mar 1, 2016 | University of Toulouse |
| NCT02259686 | Early Phase 1 (Phase 1) | Nov 1, 2014 | British Heart Foundation, NHS Lothian, University of Edinburgh |
| NCT02033473 | Phase 1 | Jan 1, 2014 | University of Toulouse |
| NCT01590108 | Phase 1 | Mar 1, 2012 | University of London |
| NCT02150694 | N/A | Jan 31, 2012 | University of Cambridge |
| NCT01457170 | N/A | Jan 1, 2012 | NHS Lothian, University of Glasgow, University of London |
| NCT01179061 | N/A | Aug 1, 2010 | University of Edinburgh |
| NCT00901719 | N/A | Apr 1, 2010 | British Heart Foundation, NHS Lothian, University of Edinburgh |
| NCT00901888 | N/A | Apr 1, 2009 | NHS Lothian, University of Edinburgh |
Showing 12 of 12 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Edinburgh | Academic/Hospital | 5 | 5 | 2 | 2009 |
| NHS Lothian | Academic/Hospital | 4 | 0 | 2 | 2009 |
| British Heart Foundation | Academic/Hospital | 2 | 0 | 2 | 2010 |
| University of Cambridge | Academic/Hospital | 2 | 2 | 2 | 2012 |
| University of London | Academic/Hospital | 2 | 1 | 2 | 2012 |
| University of Toulouse | Academic/Hospital | 2 | 2 | 1 | 2014 |
| AstraZeneca | For profit | 1 | 0 | 1 | 2018 |
| Kidney Cancer UK | Academic/Hospital | 1 | 0 | 1 | 2019 |
| University of Basel | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of Glasgow | Academic/Hospital | 1 | 1 | 1 | 2012 |
10 organizations
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