Amorolfine
Trade name: loceryl
Amorolfine, is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis. Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications was shown in two decades-old studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment were 38% and 46%. However, full experimental details of these trials were not available, and since they were first reported in 1992 there have been no subsequent trials. — Wikipedia
Clinical trial activity
16 trials · 16 clinical orgs · 0 marketing orgs
Earliest trial started Mar 1, 2007 (NCT00459537)
Timeline
Indications
Approved for
Mechanism of action
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase antagonist
Chemistry & pharmacology
SMILES
CCC(C)(C)c1ccc(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)cc1- Mol. weight
- 317.52 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAmorolfine ↗
- ChEMBLCHEMBL489411 ↗
Also known as
- allphar brand of amorolfine hydrochloride
- amorolfine
- amorolfine
- amorolfine
- amorolfine
- amorolfine
- amorolfine
- amorolfine
- amorolfine hcl
- amorolfine hcl
- amorolfine hcl
- amorolfine hydrochloride
- amorolfine hydrochloride
- amorolfin hydrochloride
- galderma brand of amorolfine hydrochloride
- isdin brand of amorolfine hydrochloride
- loceryl
- loceryl
- loceryl
- loceryl
- loceryl
- locéryl
- loceryl curanail
- locetar
- odenil
- omicur
- ro-144767000
- ro-144767000
- ro 14-4767-002
- ro-14-4767-002
- roche brand of amorolfine hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06689852 | N/A | Nov 30, 2024 | Eurofins, Oystershell NV |
| NCT06254027 | N/A | Mar 31, 2024 | Eurofins, Oystershell NV |
| NCT04961684 | N/A | Feb 10, 2020 | Eurofins, Oystershell NV |
| NCT03098342 | N/A | Jun 1, 2017 | Chulalongkorn University |
| NCT03382717 | N/A | Oct 26, 2016 | Oystershell NV, Principal Instruction military hospital of Tunis |
| NCT02812043 | Phase 4 | Aug 1, 2016 | Mahidol University |
| NCT02705664 | Phase 4 | Jan 1, 2016 | Cutis Ehf, Galderma |
| NCT02679911 | Phase 4 | Sep 1, 2015 | Galderma |
| NCT02549001 | Phase 3 | Aug 20, 2015 | Polichem S.A. |
| NCT03289871 | N/A | Jan 31, 2015 | Oystershell NV, Principal Instruction military hospital of Tunis |
| NCT02321098 | Phase 4 | Feb 1, 2014 | Galderma |
| NCT01851590 | Phase 4 | Oct 1, 2013 | Repolar Ltd., University of Helsinki |
| NCT01929187 | N/A | Feb 1, 2013 | National Taiwan University |
| NCT01528813 | Phase 2 | Feb 1, 2012 | University of Brasilia |
| NCT01014637 | Phase 4 | Aug 1, 2009 | Hopital Purpan, Pierre Fabre, QuantaBio |
| NCT00459537 | Phase 3 | Mar 1, 2007 | Novartis |
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Oystershell NV | For profit | 5 | 5 | 1 | 2015 |
| Eurofins | For profit | 3 | 0 | 1 | 2020 |
| Galderma | For profit | 3 | 3 | 1 | 2014 |
| Principal Instruction military hospital of Tunis | Government | 2 | 0 | 1 | 2015 |
| Chulalongkorn University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Cutis Ehf | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Hopital Purpan | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Mahidol University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| National Taiwan University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Novartis | For profit | 1 | 1 | 1 | 2007 |
| Pierre Fabre | For profit | 1 | 1 | 1 | 2009 |
| Polichem S.A. | For profit | 1 | 1 | 1 | 2015 |
| QuantaBio | For profit | 1 | 0 | 1 | 2009 |
| Repolar Ltd. | For profit | 1 | 0 | 1 | 2013 |
| University of Brasilia | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Helsinki | Academic/Hospital | 1 | 1 | 1 | 2013 |