apilimod mesylate
Small moleculeexperimental
Clinical trial activity
10 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
7
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2004 (NCT00088062)
Timeline
Indications
Mechanism of action
PIKFYVE inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(-c2nc(S(C)(=O)=O)[nH]c2-c2ccc(OC)cc2)cc1.CS(=O)(=O)O.CS(=O)(=O)O- Mol. weight
- 550.63 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL6067997 ↗
- ChEMBLCHEMBL4298111 ↗
Also known as
- apilimod dimesylate
- apilimod mesylate
- lam-002a
- sta5326
- sta 5326
- sta 5326
- sta 5326
- sta-5326
- sta-5326
- sta-5326
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05163886 | Phase 2 | Dec 23, 2021 | AI Therapeutics, Inc., Harvard University |
| NCT04446377 | Phase 2 | Jul 15, 2020 | AI Therapeutics, Inc., Yale University |
| NCT02594384 | Phase 1 | Oct 1, 2015 | Harvard University, LAM Therapeutics Inc. |
| NCT00263237 | Phase 1 | Dec 2, 2005 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT00642629 | Phase 2 | Dec 1, 2005 | Synta Pharmaceuticals Corp. |
| NCT00250198 | Phase 2 | Nov 3, 2005 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT00234741 | Phase 2 | Nov 1, 2005 | National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Synta Pharmaceuticals Corp. |
| NCT00138840 | Phase 2 | Aug 1, 2005 | Harvard University, Synta Pharmaceuticals Corp. |
| NCT00088062 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2004 | Synta Pharmaceuticals Corp. |
| NCT05483322 | N/A | — | AI Therapeutics, Inc. |
Showing 10 of 10 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Synta Pharmaceuticals Corp. | For profit | 4 | 4 | 1 | 2004 |
| AI Therapeutics, Inc. | For profit | 3 | 3 | 2 | 2020 |
| Harvard University | Academic/Hospital | 3 | 0 | 2 | 2005 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 3 | 2 | 2 | 2005 |
| LAM Therapeutics Inc. | For profit | 1 | 1 | 1 | 2015 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2005 |
| Yale University | Academic/Hospital | 1 | 0 | 1 | 2020 |
7 organizations
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