ammonia
[13N]Ammonia ([13N]NH3) is a useful 13N-labeled compound that has been developed as a positron emission tomography (PET) imaging agent for assessing regional blood flow in tissues. It is indicated for diagnostic PET imaging of the myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease. No adverse reactions have been reported for Ammonia N 13 Injection based on a review of the published literature, publicly available reference sources, and adverse drug reaction reporting systems. The possibility of interactions of Ammonia N 13 Injection with other drugs taken by patients undergoing PET imaging has not been studied. — NCATS
Clinical trial activity
4 trials · 4 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2013 (NCT02015195)
Timeline
2010s
- Jan 1, 2015
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
SMILES
[13NH3]- Mol. weight
- 16.02956 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaAmmonia ↗
- NCATS9OQO0E343Z ↗
- ChEMBLCHEMBL1160819 ↗
Also known as
- ammonia
- ammonia
- ammonia
- ammonia
- ammonia
- ammonia
- ammonia
- ammonia
- ammonia solution, strong
- ammonia spirit, aromatic
- ammonia water
- ammonia water
- aromatic ammonia spirit
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05868798 | Phase 1 | Oct 1, 2020 | Charles University |
| NCT04585672 | N/A | Aug 19, 2020 | Aarhus University |
| NCT02669563 | Early Phase 1 (Phase 1) | Dec 1, 2015 | University of Michigan |
| NCT02015195 | N/A | Jun 1, 2013 | Stanford University |
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Charles University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Stanford University | Academic/Hospital | 1 | 1 | 1 | 2013 |
| University of Michigan | Academic/Hospital | 1 | 1 | 1 | 2015 |