pimagedine
Small moleculeexperimental
Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, glyoxal, methylglyoxal, and related dicarbonyls. These reactive species are converted to less reactive heterocycles by this condensation reaction. — Wikipedia
Clinical trial activity
4 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Sep 30, 2003 (NCT00159380)
Timeline
2000s
- Jan 1, 2005
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Interleukin-8INHIBITOR
CXCL8 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
N=C(N)NN- Mol. weight
- 74.09 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPimagedine ↗
- ChEMBLCHEMBL225304 ↗
Also known as
- aminoguanidine
- aminoguanidine
- aminoguanidine
- aminoguanidine
- aminoguanidine sulfate
- hydrazinecarboximidamide
- hydrazinecarboximidamide
- hydrazinecarboximidamide
- monoaminoguanidine
- pimagedine
- pimagedine
- pimagedine
- pimagedine hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02099981 | Phase 1 | Jul 1, 2016 | University of Minnesota |
| NCT00184990 | Phase 1 | Jan 1, 2005 | Radboud University |
| NCT00180635 | N/A | Oct 31, 2003 | Imperial College London |
| NCT00159380 | N/A | Sep 30, 2003 | Imperial College London |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Imperial College London | Academic/Hospital | 2 | 2 | 1 | 2003 |
| Radboud University | Academic/Hospital | 1 | 1 | 1 | 2005 |
| University of Minnesota | Academic/Hospital | 1 | 1 | 1 | 2016 |
3 organizations
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