samalizumab
mAbexperimental
Samalizumab is a humanized monoclonal antibody designed for oncology indications. Samalizumab is a recombinant humanized monoclonal antibody that targets the immunoregulatory protein CD200. Results from a Phase I study indicated the drug has potential for use in treating cancers including chronic lymphocytic leukemia. — Wikipedia
Clinical trial activity
3 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2008 (NCT00648739)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- OX-2 membrane glycoproteinINHIBITOR
CD200 inhibitor
Blocks binding of CD200 to the CD200 receptor. Induces Ab-dependent cellular cytotoxicity of activated T cells.
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSamalizumab ↗
- ChEMBLCHEMBL1743067 ↗
Also known as
- alxn6000
- alxn-6000
- samalizumab
- samalizumab
- samalizumab
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02987504 | Phase 1 | Nov 1, 2016 | Alexion, IQVIA |
| NCT03013998 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2016 | Beat AML |
| NCT00648739 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2008 | Alexion, Duke University, Emory University, HOANNJ-Carol G. Simon Cancer Center, University of Arizona, University of Michigan |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Alexion | For profit | 2 | 2 | 2 | 2008 |
| Beat AML | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Emory University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| HOANNJ-Carol G. Simon Cancer Center | Academic/Hospital | 1 | 0 | 1 | 2008 |
| IQVIA | For profit | 1 | 0 | 1 | 2016 |
| University of Arizona | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Michigan | Academic/Hospital | 1 | 0 | 1 | 2008 |
8 organizations
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