dentin
Dentin or dentine is a calcified tissue of the body and, along with enamel, cementum, and pulp, is one of the four major components of teeth. It is usually covered by enamel on the crown and cementum on the root and surrounds the entire pulp. By volume, 45% of dentin consists of the mineral hydroxyapatite, 33% is organic material, and 22% is water. Yellow in appearance, it greatly affects the color of a tooth due to the translucency of enamel. Dentin, which is less mineralized and less brittle than enamel, is necessary for the support of enamel. Dentin rates approximately 3 on the Mohs scale of mineral hardness. There are two main characteristics which distinguish dentin from enamel: firstly, dentin forms throughout life; secondly, dentin is sensitive and can become hypersensitive to changes in temperature due to the sensory function of odontoblasts, especially when enamel recedes and dentin channels become exposed. — Wikipedia
Clinical trial activity
8 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2015 (NCT02635867)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetTissue restoration
tissue restoration
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07242313 | N/A | Oct 21, 2025 | Kafrelsheikh University, National Research Center, Egypt |
| NCT06827665 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2025 | Jordan University, University of Jordan |
| NCT06552793 | N/A | May 1, 2024 | Cairo University |
| NCT07207382 | Phase 3 | Feb 20, 2024 | Ain Shams University |
| NCT06318650 | N/A | Feb 1, 2024 | Cairo University |
| NCT06048042 | Phase 4 | Sep 30, 2023 | Cairo University |
| NCT06853392 | Phase 3 | Sep 15, 2023 | Al Azhar University, Beni Suef University |
| NCT02635867 | N/A | Jun 1, 2015 | University of Illinois at Chicago |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 3 | 3 | 2 | 2023 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Al Azhar University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Beni Suef University | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Jordan University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Kafrelsheikh University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| National Research Center, Egypt | Government | 1 | 0 | 1 | 2025 |
| University of Illinois at Chicago | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Jordan | Academic/Hospital | 1 | 0 | 1 | 2025 |