dentin

Biologicalexperimental

Dentin or dentine is a calcified tissue of the body and, along with enamel, cementum, and pulp, is one of the four major components of teeth. It is usually covered by enamel on the crown and cementum on the root and surrounds the entire pulp. By volume, 45% of dentin consists of the mineral hydroxyapatite, 33% is organic material, and 22% is water. Yellow in appearance, it greatly affects the color of a tooth due to the translucency of enamel. Dentin, which is less mineralized and less brittle than enamel, is necessary for the support of enamel. Dentin rates approximately 3 on the Mohs scale of mineral hardness. There are two main characteristics which distinguish dentin from enamel: firstly, dentin forms throughout life; secondly, dentin is sensitive and can become hypersensitive to changes in temperature due to the sensory function of odontoblasts, especially when enamel recedes and dentin channels become exposed. — Wikipedia

Clinical trial activity

8 trials · 9 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
3
Phase 3
2
Phase 4
1

Earliest trial started Jun 1, 2015 (NCT02635867)

Timeline

2020s

  1. Jan 1, 2023

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2025

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Mechanism of action

  • Unspecified targetTissue restoration

    tissue restoration

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • dentin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07242313N/AOct 21, 2025Kafrelsheikh University, National Research Center, Egypt
NCT06827665Phase 1/Phase 2 (Phase 2)Jan 1, 2025Jordan University, University of Jordan
NCT06552793N/AMay 1, 2024Cairo University
NCT07207382Phase 3Feb 20, 2024Ain Shams University
NCT06318650N/AFeb 1, 2024Cairo University
NCT06048042Phase 4Sep 30, 2023Cairo University
NCT06853392Phase 3Sep 15, 2023Al Azhar University, Beni Suef University
NCT02635867N/AJun 1, 2015University of Illinois at Chicago
Showing 8 of 8 trials
Page 1 / 1

Organizations

Research & Development (9)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Cairo UniversityAcademic/Hospital3322023
Ain Shams UniversityAcademic/Hospital1112024
Al Azhar UniversityAcademic/Hospital1112023
Beni Suef UniversityAcademic/Hospital1012023
Jordan UniversityAcademic/Hospital1112025
Kafrelsheikh UniversityAcademic/Hospital1112025
National Research Center, EgyptGovernment1012025
University of Illinois at ChicagoAcademic/Hospital1112015
University of JordanAcademic/Hospital1012025
9 organizations
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