ralimetinib
Small moleculeexperimental
Ralimetinib (LY2228820) is a small molecule experimental cancer drug in development by Eli Lilly. Although originally thought to be a p38 mitogen-activated protein kinase (MAPK) inhibitor, it has since been reported that it acts instead as an epidermal growth factor receptor (EGFR) inhibitor. — Wikipedia
Clinical trial activity
5 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2008 (NCT01393990)
Timeline
Indications
Mechanism of action
- MAP kinase p38 alphaINHIBITOR
MAPK14 inhibitor
Also potent inhibitor or MAPK11
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(C)Cn1c(N)nc2ccc(-c3[nH]c(C(C)(C)C)nc3-c3ccc(F)cc3)nc21- Mol. weight
- 420.54 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaRalimetinib ↗
- ChEMBLCHEMBL2364626 ↗
Also known as
- ly2228820
- ly2228820
- ly-2228820
- ly-2228820
- ly-22288220
- ly-22288220
- ralimetinib
- ralimetinib
- ralimetinib
- ralimetinib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02860780 | Phase 1 | Aug 1, 2016 | Eli Lilly |
| NCT02364206 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2015 | Centre Jean Perrin, Fondation ARC, National Cancer Institute, France |
| NCT02322853 | Phase 2 | Jan 1, 2015 | Fondation ARC, National Cancer Institute, France, University of Caen-Normandie |
| NCT01663857 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2012 | Eli Lilly |
| NCT01393990 | Phase 1 | Aug 1, 2008 | Eli Lilly |
Showing 5 of 5 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Eli Lilly | For profit | 3 | 3 | 2 | 2008 |
| Fondation ARC | Academic/Hospital | 2 | 0 | 1 | 2015 |
| National Cancer Institute, France | Government | 2 | 0 | 1 | 2015 |
| Centre Jean Perrin | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Caen-Normandie | Academic/Hospital | 1 | 1 | 1 | 2015 |
5 organizations
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