pyridoxamine
Small moleculeexperimental
Pyridoxamine (PM) is one form of vitamin B6. Chemically it is based on a pyridine ring structure, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents. It differs from pyridoxine by the substituent at the 4-position. The hydroxyl at position 3 and aminomethyl group at position 4 of its ring endow pyridoxamine with a variety of chemical properties, including the scavenging of free radical species and carbonyl species formed in sugar and lipid degradation and chelation of metal ions that catalyze Amadori reactions. — Wikipedia
Clinical trial activity
9 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
6
Phase 3
1
Phase 4
0
Earliest trial started Oct 1, 2001 (NCT00320060)
Timeline
Indications
Studied for
- Aging · Phase 1/Phase 2
- Cardiovascular Diseases · Early Phase 1
- Cognitive Dysfunction · Early Phase 1
- Depression · Early Phase 1
- Diabetic Nephropathies · Phase 3
- Disability Evaluation · Early Phase 1
- Hormones · Early Phase 1
- Hyperlipidemias · Early Phase 1
- Hyperphagia · Early Phase 1
- Hypertension · Early Phase 1
- Inflammation · Early Phase 1
- Insulin Resistance · Early Phase 1
- Kidney Calculi · Phase 2
- Obesity · Phase 1/Phase 2
- Sedentary Behavior · Early Phase 1
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
Cc1ncc(CO)c(CN)c1O- Mol. weight
- 168.2 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPyridoxamine ↗
- ChEMBLCHEMBL593019 ↗
- ChEMBLCHEMBL4298078 ↗
Also known as
- pyridorin
- pyridorin
- pyridorin
- pyridoxamine
- pyridoxamine
- pyridoxamine
- pyridoxamine dihydrochloride
- pyridoxamine dihydrochloride
- pyridoxamine dihydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06242535 | Early Phase 1 (Phase 1) | Jul 27, 2023 | Buck Institute for Research on Aging, Hoskinson Health and Wellness Clinic, University of Wyoming |
| NCT05083546 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2022 | University of California, San Francisco |
| NCT03778580 | N/A | Mar 1, 2018 | Columbia University |
| NCT02954588 | N/A | Oct 1, 2016 | Maastricht University, Top Institute Food and Nutrition |
| NCT02156843 | Phase 3 | Jun 1, 2014 | Medpace, Inc., NephroGenex, Inc. |
| NCT00734253 | Phase 2 | Aug 1, 2008 | Medpace, Inc., NephroGenex, Inc. |
| NCT00490113 | Phase 2 | Jan 1, 2007 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Kansas |
| NCT00320021 | Phase 2 | Jul 1, 2002 | BioStratum |
| NCT00320060 | Phase 2 | Oct 1, 2001 | BioStratum |
Showing 9 of 9 trials
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Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BioStratum | For profit | 2 | 2 | 1 | 2001 |
| Medpace, Inc. | For profit | 2 | 0 | 2 | 2008 |
| NephroGenex, Inc. | For profit | 2 | 2 | 2 | 2008 |
| Buck Institute for Research on Aging | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Columbia University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Hoskinson Health and Wellness Clinic | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 0 | 1 | 2007 |
| Top Institute Food and Nutrition | Academic/Hospital | 1 | 0 | 1 | 2016 |
| University of California, San Francisco | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Kansas | Academic/Hospital | 1 | 1 | 1 | 2007 |
| University of Wyoming | Academic/Hospital | 1 | 0 | 1 | 2023 |
12 organizations
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