virginiamycin

Small moleculeexperimental

Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent microbial contamination. It is also used in agriculture, specifically in livestock, to accelerate the growth of the animals and to prevent and treat infections. Antibiotics also save as much as 30% in feed costs among young swine, although the savings fade as pigs get older, according to a USDA study. — Wikipedia

Clinical trial activity

2 trials · 1 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Oct 1, 2006 (NCT00393744)

Timeline

2000s

Jan 1, 2006
Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Bacterial Infections

Studied for

Mechanism of action

23S rRNA methylase leader peptideINHIBITOR
ermC inhibitor
- 23S rRNA methylase leader peptide (ermC) ↗

Chemistry & pharmacology

Loading structure…

SMILES

CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]3CC(=O)CCN3C(=O)[C@H](Cc4ccc(cc4)N(C)C)N(C)C(=O)[C@@H]5CCCN5C1=O)c6ccccc6.CC(C)[C@H]7OC(=O)C8=CCCN8C(=O)c9coc(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]7C)n9

Mol. weight: 1392.57 g/mol
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

Also known as

mikamycin
mikamycin
mikamycin
pristinamycin
pristinamycin
pristinamycin
pristinamycin
pristinamycine
pristinamycine
pristinamycine
pyostacine
pyostacine
pyostacine
rp-7293
rp-7293
streptogramin
virgimycin
virginiamycin
virginiamycin
virginiamycin
virginiamycin

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT02332577	Phase 4	Apr 1, 2015	Sanofi
NCT00393744	Phase 3	Oct 1, 2006	Sanofi

Showing 2 of 2 trials

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Organizations

Research & Development (1)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Sanofi	For profit	2	2	2	2006

1 organizations

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