pracinostat
Small moleculeexperimental
Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor based on hydroxamic acid with potential anti-tumor activity characterized by favorable physicochemical, pharmaceutical, and pharmacokinetic properties. — Wikipedia
Clinical trial activity
16 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
9
Phase 3
1
Phase 4
0
Earliest trial started Apr 1, 2007 (NCT00741234)
Timeline
Indications
Studied for
- Healthy Volunteers · Phase 1
- Hematologic Neoplasms · Phase 1
- Leukemia · Phase 1
- Leukemia, Myeloid, Acute · Phase 3
- Myelodysplastic Syndromes · Phase 2
- Myeloproliferative Disorders · Phase 2
- Neoplasm Metastasis · Phase 2
- Neoplasms · Phase 1
- Nicotiana · Early Phase 1
- Non-Smokers · Phase 1
- Prostatic Neoplasms · Phase 2
Mechanism of action
- Histone deacetylase 2INHIBITOR
HDAC2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCCCc1nc2cc(/C=C/C(=O)NO)ccc2n1CCN(CC)CC- Mol. weight
- 358.49 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPracinostat ↗
- ChEMBLCHEMBL1851943 ↗
Also known as
- 3-(2-butyl-1-(2-diethylaminoethyl)-1h-benzoimidazol-5-yl)-n-hydroxyacrylamide-hydrochloride
- pracinostat
- pracinostat
- pracinostat
- pracinostat
- sb939
- sb939
- sb939 compound
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03848754 | Phase 1 | May 24, 2019 | Medical College of Wisconsin |
| NCT03495934 | Phase 1 | Feb 8, 2018 | Helsinn, Quotient |
| NCT03151408 | Phase 3 | Jun 1, 2017 | Clinipace LTD, Helsinn, University of Texas at Houston |
| NCT03151304 | Phase 2 | Jun 1, 2017 | Helsinn, MEI Pharma, University of Texas at Houston |
| NCT02267278 | Phase 2 | Jan 12, 2015 | MEI Pharma, University of Texas at Houston |
| NCT02118909 | Phase 1 | May 1, 2014 | Celerion, Helsinn |
| NCT02058784 | Early Phase 1 (Phase 1) | Feb 1, 2014 | Celerion, Helsinn |
| NCT01993641 | Phase 2 | Dec 1, 2013 | Helsinn, University of Texas at Houston |
| NCT01912274 | Phase 2 | Oct 1, 2013 | Helsinn, University of Texas at Houston |
| NCT01873703 | Phase 2 | Jun 1, 2013 | Helsinn, University of Texas at Houston |
| NCT01200498 | Phase 2 | Nov 1, 2010 | S*BIO, University of Texas at Houston |
| NCT01184274 | Phase 1 | Sep 1, 2010 | Canadian Cancer Trials Group, University of Toronto |
| NCT01112384 | Phase 2 | Mar 1, 2010 | Canadian Cancer Trials Group, University of Alberta |
| NCT01075308 | Phase 2 | Feb 1, 2010 | British Columbia Cancer Agency, Canadian Cancer Trials Group, University of Calgary |
| NCT00504296 | Phase 1 | Jun 1, 2007 | Canadian Cancer Trials Group, University of Toronto |
| NCT00741234 | Phase 1 | Apr 1, 2007 | National University of Singapore, S*BIO, Singapore General Hospital, The National Cancer Center, University of Texas at Houston, University of Wisconsin |
Showing 16 of 16 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Helsinn | For profit | 8 | 8 | 3 | 2013 |
| University of Texas at Houston | Academic/Hospital | 8 | 2 | 3 | 2007 |
| Canadian Cancer Trials Group | Academic/Hospital | 4 | 4 | 2 | 2007 |
| Celerion | For profit | 2 | 0 | 1 | 2014 |
| MEI Pharma | For profit | 2 | 0 | 1 | 2015 |
| S*BIO | For profit | 2 | 1 | 2 | 2007 |
| University of Toronto | Academic/Hospital | 2 | 0 | 1 | 2007 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Clinipace LTD | For profit | 1 | 0 | 1 | 2017 |
| Medical College of Wisconsin | Academic/Hospital | 1 | 1 | 1 | 2019 |
| National University of Singapore | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Quotient | For profit | 1 | 0 | 1 | 2018 |
| Singapore General Hospital | Academic/Hospital | 1 | 0 | 1 | 2007 |
| The National Cancer Center | Academic/Hospital | 1 | 0 | 1 | 2007 |
| University of Alberta | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Calgary | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Wisconsin | Academic/Hospital | 1 | 0 | 1 | 2007 |
17 organizations
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