phenserine
Small moleculeexperimental
Clinical trial activity
8 trials · 14 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
4
Phase 3
4
Phase 4
0
Earliest trial started Feb 1, 2010 (NCT01072812)
Timeline
Indications
Mechanism of action
- AcetylcholinesteraseINHIBITOR
ACHE inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CC[C@]2(C)c3cc(OC(=O)Nc4ccccc4)ccc3N(C)[C@H]12- Mol. weight
- 337.42 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297417 ↗
Also known as
- n-phenylcarbamoyleseroline
- n-phenylcarbamoyl eseroline
- phenserine
- phenserine
- posiphen
- posiphen
- posiphen
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07284784 | Phase 2/Phase 3 (Phase 3) | Jan 31, 2026 | Annovis Bio Inc., Duke University |
| NCT06774261 | Phase 1 | Feb 1, 2025 | Helse Fonna, National Institutes of Health (NIH), Norwegian University of Science and Technology, University Hospital of North Norway, University of Exeter, University of Stavanger |
| NCT06709014 | Phase 3 | Jan 31, 2025 | Annovis Bio Inc., Prevail Infoworks, Inc |
| NCT05686044 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2023 | Annovis Bio Inc. |
| NCT05357989 | Phase 3 | Aug 3, 2022 | Annovis Bio Inc., TFS Trial Form Support |
| NCT04524351 | Phase 1/Phase 2 (Phase 2) | Aug 14, 2020 | Annovis Bio Inc., Parexel |
| NCT02925650 | Phase 1/Phase 2 (Phase 2) | Mar 2, 2017 | Annovis Bio, National Institute on Aging (NIA) |
| NCT01072812 | Phase 1 | Feb 1, 2010 | Annovis Bio, CEDRA Clinical Research |
Showing 8 of 8 trials
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Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Annovis Bio Inc. | For profit | 5 | 5 | 2 | 2020 |
| Annovis Bio | For profit | 2 | 2 | 2 | 2010 |
| CEDRA Clinical Research | For profit | 1 | 0 | 1 | 2010 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2026 |
| Helse Fonna | Academic/Hospital | 1 | 0 | 1 | 2025 |
| National Institute on Aging (NIA) | Government | 1 | 0 | 1 | 2017 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2025 |
| Norwegian University of Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Parexel | For profit | 1 | 0 | 1 | 2020 |
| Prevail Infoworks, Inc | For profit | 1 | 0 | 1 | 2025 |
| TFS Trial Form Support | For profit | 1 | 0 | 1 | 2022 |
| University Hospital of North Norway | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Exeter | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Stavanger | Academic/Hospital | 1 | 1 | 1 | 2025 |
14 organizations
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