alagebrium
Alagebrium was a drug candidate developed by Alteon, Inc. It was the first drug candidate to be clinically tested for the purpose of breaking the crosslinks caused by advanced glycation endproducts (AGEs), thereby reversing one of the main mechanisms of aging. Through this effect Alagebrium is designed to reverse the stiffening of blood vessel walls that contributes to hypertension and cardiovascular disease, as well as many other forms of degradation associated with protein crosslinking. Alagebrium has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic heart failure. — Wikipedia
Clinical trial activity
13 trials · 14 clinical orgs · 0 marketing orgs
Earliest trial started Aug 1, 2001 (NCT00045994)
Timeline
2000s
- Jan 1, 2001
Earliest Phase 2 Sponsor(trial)
Indications
Studied for
- Aging · Phase 2/Phase 3
- Cardiovascular Diseases · Phase 2/Phase 3
- Diabetes Mellitus, Type 1 · Phase 2
- Diabetic Nephropathies · Phase 2
- Dyspnea · Phase 2
- Endothelial Cells · Phase 2/Phase 3
- Exercise · Phase 2/Phase 3
- Heart Failure · Phase 2
- Heart Failure, Diastolic · Phase 2
- Hypertension · Phase 2
- Hypertrophy, Left Ventricular · Phase 2
- Pulmonary Edema · Phase 2
- Ventricular Function · Phase 2
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
SMILES
Cc1sc[n+](CC(=O)c2ccccc2)c1C- Mol. weight
- 232.33 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2111081 ↗
- WikipediaAlagebrium ↗
- ChEMBLCHEMBL2107309 ↗
Also known as
- 3-phenacyl-4,5-dimethylthiazolium chloride
- alagebrium
- alagebrium
- alagebrium
- alagebrium
- alagebrium
- alagebrium chloride
- alagebrium chloride
- alt711
- alt 711
- alt-711
- alt-711
- alt-711
- alt-711
- phenyl-4,5-dimethylthiazolium chloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01417663 | Phase 2/Phase 3 (Phase 3) | Nov 1, 2008 | Dutch Heart Foundation, Radboud University, Synvista Therapeutics, Inc |
| NCT00739687 | Phase 2 | Aug 1, 2008 | Synvista Therapeutics, Inc |
| NCT01014572 | Phase 2 | Jul 1, 2008 | The University of Texas, Dallas |
| NCT00662116 | Phase 2 | Mar 1, 2008 | Synvista Therapeutics, Inc, University of Michigan |
| NCT01913301 | Phase 2 | Dec 1, 2007 | Cardiovascular Clinical Studies, Inc. |
| NCT00557518 | Phase 2 | Nov 1, 2007 | Juvenile Diabetes Research Foundation, Monash University, Synvista Therapeutics, Inc |
| NCT00516646 | Phase 2 | Aug 1, 2007 | Synvista Therapeutics, Inc, University of Groningen |
| NCT00302250 | Phase 2 | Feb 1, 2006 | Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Synvista Therapeutics, Inc |
| NCT00089713 | Phase 2 | Mar 1, 2004 | Synvista Therapeutics, Inc |
| NCT00277875 | Phase 2 | Feb 1, 2004 | Johns Hopkins University, National Institutes of Health (NIH), Synvista Therapeutics, Inc |
| NCT00043836 | Phase 2 | Jul 1, 2002 | Medical University of South Carolina, Synvista Therapeutics, Inc, Wake Forest University |
| NCT00045981 | Phase 2 | Oct 1, 2001 | Synvista Therapeutics, Inc |
| NCT00045994 | Phase 2 | Aug 1, 2001 | Synvista Therapeutics, Inc |
Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Synvista Therapeutics, Inc | For profit | 11 | 10 | 2 | 2001 |
| Johns Hopkins University | Academic/Hospital | 2 | 0 | 1 | 2004 |
| National Institutes of Health (NIH) | Government | 2 | 0 | 1 | 2004 |
| Cardiovascular Clinical Studies, Inc. | For profit | 1 | 1 | 1 | 2007 |
| Dutch Heart Foundation | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Juvenile Diabetes Research Foundation | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Medical University of South Carolina | Academic/Hospital | 1 | 0 | 1 | 2002 |
| Monash University | Academic/Hospital | 1 | 0 | 1 | 2007 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2006 |
| Radboud University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of Groningen | Academic/Hospital | 1 | 0 | 1 | 2007 |
| University of Michigan | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Wake Forest University | Academic/Hospital | 1 | 0 | 1 | 2002 |