cerlapirdine
Small moleculeexperimental
Cerlapirdine is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. In a phase II clinical trial it demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events, but no further development has occurred since 2011. — Wikipedia
Clinical trial activity
12 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
10
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2006 (NCT00479297)
Timeline
Indications
Mechanism of action
- Serotonin 6 (5-HT6) receptorANTAGONIST
HTR6 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CN(C)CCCOc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1- Mol. weight
- 409.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCerlapirdine ↗
- ChEMBLCHEMBL2103880 ↗
Also known as
- cerlapirdine
- cerlapirdine
- cerlapirdine
- pf-05212365
- pf-05212365
- pf-05212365
- sam-531
- sam-531
- sam-531
- sam-531
- way-262531
- way-262531
- way-262531
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01253655 | Phase 1 | Nov 1, 2010 | Pfizer, Yale University |
| NCT00966966 | Phase 1 | Sep 1, 2009 | Pfizer |
| NCT00906191 | Phase 1 | May 1, 2009 | Pfizer, Wyeth |
| NCT00895895 | Phase 2 | May 1, 2009 | Pfizer |
| NCT00745576 | Phase 1 | Oct 1, 2008 | Pfizer, Wyeth |
| NCT00726115 | Phase 1 | Aug 1, 2008 | Pfizer, Wyeth |
| NCT00519298 | Phase 1 | Oct 1, 2007 | Pfizer, Wyeth |
| NCT00481520 | Phase 2 | Jun 1, 2007 | Pfizer, Wyeth |
| NCT00479349 | Phase 1 | May 1, 2007 | Pfizer, Wyeth |
| NCT00480818 | Phase 1 | Sep 1, 2006 | Pfizer, Wyeth |
| NCT00479297 | Phase 1 | May 1, 2006 | Pfizer, Wyeth |
| NCT00479700 | Phase 1 | May 1, 2006 | Pfizer, Wyeth |
Showing 12 of 12 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 12 | 12 | 2 | 2006 |
| Wyeth | For profit | 9 | 0 | 2 | 2006 |
| Yale University | Academic/Hospital | 1 | 0 | 1 | 2010 |
3 organizations
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