voruciclib
Small moleculeexperimental
Clinical trial activity
5 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Dec 1, 2008 (NCT00840190)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Hematologic Neoplasms · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Lymphoma, B-Cell, Marginal Zone · Phase 1
- Lymphoma, Follicular · Phase 1
- Lymphoma, Large B-Cell, Diffuse · Phase 1
- Lymphoma, Mantle-Cell · Phase 1
- Lymphoma, Primary Cutaneous Anaplastic Large Cell · Phase 1
- Melanoma · Phase 1
- Neoplasms · Phase 1
Mechanism of action
- Cyclin-dependent kinase 4INHIBITOR
CDK4 inhibitor
Also thought to inhibit CDK1, CDK6 and CDK9 (http://www.bloodjournal.org/content/122/21/1636?sso-checked=true)
Chemistry & pharmacology
Loading structure…
SMILES
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO- Mol. weight
- 469.84 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3905910 ↗
- ChEMBLCHEMBL3545218 ↗
Also known as
- p1446a-05
- p1446a-05
- voruciclib
- voruciclib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03547115 | Phase 1 | May 31, 2018 | MEI Pharma |
| NCT02117336 | Phase 1 | Jun 1, 2014 | Dartmouth University, Harvard University, Piramal |
| NCT01841463 | Phase 1 | Aug 1, 2013 | Melanoma Research Foundation Breakthrough Consortium, Piramal, University of California, San Francisco, University of Texas at Houston |
| NCT00772876 | Phase 1 | Dec 1, 2008 | British Columbia Cancer Agency, Piramal, University of Alberta, University of Calgary, University of Western Ontario |
| NCT00840190 | Phase 1 | Dec 1, 2008 | Piramal |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Piramal | For profit | 4 | 4 | 1 | 2008 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Dartmouth University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| MEI Pharma | For profit | 1 | 1 | 1 | 2018 |
| Melanoma Research Foundation Breakthrough Consortium | Academic/Hospital | 1 | 0 | 1 | 2013 |
| University of Alberta | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Calgary | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of California, San Francisco | Academic/Hospital | 1 | 0 | 1 | 2013 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2013 |
| University of Western Ontario | Academic/Hospital | 1 | 0 | 1 | 2008 |
11 organizations
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